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Gene Review

ceh-10  -  Protein CEH-10

Caenorhabditis elegans

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High impact information on ceh-10

  • In contrast, the acquisition of several pan-neuronal features is unaffected in ceh-10 and ttx-3 mutants, suggesting that the activity of these homeobox genes separates pan-neuronal from subtype-specific differentiation programs [1].
  • We describe the homeobox gene ceh-10 from the nematode Caenorhabditis elegans [2].
  • As assayed in transgenic worms, the promoter region of ceh-10 directs expression of a lacZ reporter gene to a small number of neurons [2].
  • Transcripts of ceh-10 and ceh-11 are present in embryonic RNA but are greatly diminished in later developmental stages [3].
  • Comparison of the amino acid sequences of Vsx-2, Vsx-1, Chx10, and C. elegans ceh-10 reveal a conserved homeodomain and a unique domain termed the CVC domain [4].

Other interactions of ceh-10

  • The C. elegans neuronally expressed homeobox gene ceh-10 is closely related to genes expressed in the vertebrate eye [2].


  1. A regulatory cascade of three homeobox genes, ceh-10, ttx-3 and ceh-23, controls cell fate specification of a defined interneuron class in C. elegans. Altun-Gultekin, Z., Andachi, Y., Tsalik, E.L., Pilgrim, D., Kohara, Y., Hobert, O. Development (2001) [Pubmed]
  2. The C. elegans neuronally expressed homeobox gene ceh-10 is closely related to genes expressed in the vertebrate eye. Svendsen, P.C., McGhee, J.D. Development (1995) [Pubmed]
  3. Homeobox containing genes in the nematode Caenorhabditis elegans. Hawkins, N.C., McGhee, J.D. Nucleic Acids Res. (1990) [Pubmed]
  4. Vsx-1 and Vsx-2: two Chx10-like homeobox genes expressed in overlapping domains in the adult goldfish retina. Levine, E.M., Passini, M., Hitchcock, P.F., Glasgow, E., Schechter, N. J. Comp. Neurol. (1997) [Pubmed]
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