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Gene Review

rbf-1  -  Protein RBF-1

Caenorhabditis elegans

 
 
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Psychiatry related information on rbf-1

 

High impact information on rbf-1

  • In the present study we showed by means of deletion and mutation analyses that rabphilin and Noc2 are recruited to dense-core vesicles through specific interaction with Rab27A, not with Rab3A, in PC12 cells [2].
  • Rabphilin potentiates soluble N-ethylmaleimide sensitive factor attachment protein receptor function independently of rab3 [1].
  • Furthermore, rabphilin mutations display strong synergistic interactions with hypomorphic lesions in the syntaxin, synaptosomal-associated protein of 25 kDa, and synaptobrevin soluble N-ethylmaleimide sensitive factor attachment protein receptor (SNARE) genes; double mutants were nonresponsive to mechanical stimulation [1].

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