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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

adr-2  -  Protein ADR-2

Caenorhabditis elegans

 
 
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High impact information on adr-2

  • We find, however, that transgenes expressed in the somatic tissues of wild-type animals are silenced in strains with deletions in the two genes encoding ADARs, adr-1 and adr-2 [1].
  • The Caenorhabditis elegans T20H4.4 open reading frame (GenBank accession no. U00037) predicted by Genefinder encodes a 367 amino acid protein that is 32-35% identical to the C-terminal domain of adenosine deaminases that act on RNA [2].
 

Other interactions of adr-2

  • We describe the two C.elegans ADAR genes, adr-1 and adr-2, and characterize strains containing homozygous deletions in each, or both, of these genes [3].

References

  1. The role of RNA editing by ADARs in RNAi. Knight, S.W., Bass, B.L. Mol. Cell (2002) [Pubmed]
  2. Caenorhabditis elegans mRNAs that encode a protein similar to ADARs derive from an operon containing six genes. Hough, R.F., Lingam, A.T., Bass, B.L. Nucleic Acids Res. (1999) [Pubmed]
  3. RNA editing by ADARs is important for normal behavior in Caenorhabditis elegans. Tonkin, L.A., Saccomanno, L., Morse, D.P., Brodigan, T., Krause, M., Bass, B.L. EMBO J. (2002) [Pubmed]
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