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Gene Review:

cdh-3 - Protein CDH-3

Caenorhabditis elegans

Pettitt, J. et al., Kirouac, M. et al.

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High impact information on cdh-3

cdh-3, a gene encoding a member of the cadherin superfamily, functions in epithelial cell morphogenesis in Caenorhabditis elegans [1].
We generated a loss-of-function mutation in cdh-3 by transposon-mediated deletion mutagenesis [1].
Reporter genes under the control of upstream sequences from one of these genes, cdh-3, are expressed in developing epithelial cells, but also in a number of neuroectodermal cells that extend processes along some of these epithelial cells [1].
These regions of similarity in C. elegans and C. briggsae upstream of egl-17, zmp-1, and cdh-3 promote expression in vulval cells and the anchor cell (AC) [2].

References

cdh-3, a gene encoding a member of the cadherin superfamily, functions in epithelial cell morphogenesis in Caenorhabditis elegans. Pettitt, J., Wood, W.B., Plasterk, R.H. Development (1996) [Pubmed]
cis-Regulatory control of three cell fate-specific genes in vulval organogenesis of Caenorhabditis elegans and C. briggsae. Kirouac, M., Sternberg, P.W. Dev. Biol. (2003) [Pubmed]

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