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Gene Review

glb-1  -  Protein GLB-1

Caenorhabditis elegans

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Disease relevance of Globin

  • The single polypeptide chain consists of two domains, each of which can be expressed separately in Escherichia coli as a globin-like protein exhibiting oxygen binding characteristics comparable with the native molecule [1].

High impact information on Globin


Biological context of Globin

  • The two introns common to virtually all animal and plant Glo genes are missing [2].

Analytical, diagnostic and therapeutic context of Globin

  • An initiation codon preceded the globin but the sequence upstream (extending for 30 nucleotides to the vector ligation site) had characteristics both of the code for a protein hydrophobic leader and of a trans-spliced RNA leader [3].
  • The adult stage globin-like antigen (OoAdGlb) was purified from total worm extracts by liquid chromatography [4].


  1. The tyrosine B10 hydroxyl is crucial for oxygen avidity of Ascaris hemoglobin. Kloek, A.P., Yang, J., Mathews, F.S., Frieden, C., Goldberg, D.E. J. Biol. Chem. (1994) [Pubmed]
  2. Novel gene structure and evolutionary context of Caenorhabditis elegans globin. Kloek, A.P., Sherman, D.R., Goldberg, D.E. Gene (1993) [Pubmed]
  3. Expression of a globin gene in Caenorhabditis elegans. Mansell, J.B., Timms, K., Tate, W.P., Moens, L., Trotman, C.N. Biochem. Mol. Biol. Int. (1993) [Pubmed]
  4. Isolation, characterization and immunolocalization of a globin-like antigen from Ostertagia ostertagi adults. de Graaf, D.C., Berghen, P., Moens, L., de Marez, T.M., Raes, S., Blaxter, M.L., Vercruysse, J. Parasitology (1996) [Pubmed]
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