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Gene Review:

glb-1 - Protein GLB-1

Caenorhabditis elegans

Kloek, A.P. et al., Mansell, J.B. et al., Kloek, A.P. et al., de Graaf, D.C. et al.

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Disease relevance of Globin

The single polypeptide chain consists of two domains, each of which can be expressed separately in Escherichia coli as a globin-like protein exhibiting oxygen binding characteristics comparable with the native molecule [1].

High impact information on Globin

Animal and plant globin-encoding genes (Glo) contain two introns in strictly conserved positions [2].
Comparison with the related organisms Trichostrongylus colubriformis, Ascaris suum and Pseudoterranova decipiens, provides evidence of gene duplication, intron loss, and functional divergence within the Glo genes of the nematode phylum [2].
Oligonucleotides related to parts of a globin-like sequence in the genome of Caenorhabditis elegans were used to probe a cDNA library from the same species [3].

Biological context of Globin

The two introns common to virtually all animal and plant Glo genes are missing [2].

Analytical, diagnostic and therapeutic context of Globin

An initiation codon preceded the globin but the sequence upstream (extending for 30 nucleotides to the vector ligation site) had characteristics both of the code for a protein hydrophobic leader and of a trans-spliced RNA leader [3].
The adult stage globin-like antigen (OoAdGlb) was purified from total worm extracts by liquid chromatography [4].

References

The tyrosine B10 hydroxyl is crucial for oxygen avidity of Ascaris hemoglobin. Kloek, A.P., Yang, J., Mathews, F.S., Frieden, C., Goldberg, D.E. J. Biol. Chem. (1994) [Pubmed]
Novel gene structure and evolutionary context of Caenorhabditis elegans globin. Kloek, A.P., Sherman, D.R., Goldberg, D.E. Gene (1993) [Pubmed]
Expression of a globin gene in Caenorhabditis elegans. Mansell, J.B., Timms, K., Tate, W.P., Moens, L., Trotman, C.N. Biochem. Mol. Biol. Int. (1993) [Pubmed]
Isolation, characterization and immunolocalization of a globin-like antigen from Ostertagia ostertagi adults. de Graaf, D.C., Berghen, P., Moens, L., de Marez, T.M., Raes, S., Blaxter, M.L., Vercruysse, J. Parasitology (1996) [Pubmed]

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