Disease relevance of Trichostrongylus

• Treatment with closantel (7.5 mg/kg) at the same times was very effective against H. contortus but ineffective against Trichostrongylus spp; 25% of lambs had to be withdrawn because of severe trichostrongylosis [1].
• AIMS: To determine the efficacy of eprinomectin, doramectin and a combination of albendazole and levamisole in suppressing or eliminating nematode infections or faecal egg counts (FEC) in possums naturally or experimentally infected with Parastrongyloides trichosuri, Paraustrostrongylus trichosuri and Trichostrongylus colubriformis [2].

High impact information on Trichostrongylus

• Experiments on red grouse Lagopus lagopus scoticus have shown that population instability can be caused both by the effects of a parasitic nematode, Trichostrongylus tenuis, on host production or by changes in testosterone influencing aggressive behaviour and recruitment [3].
• Cloning and sequence analysis of the candidate nicotinic acetylcholine receptor alpha subunit gene tar-1 from Trichostrongylus colubriformis [4].
• Identification and characterisation of an aspartyl protease inhibitor homologue as a major allergen of Trichostrongylus colubriformis [5].
• The effect of infection of sheep with the gastrointestinal nematode parasite Trichostrongylus colubriformis on expression of adhesion molecules CD11a, CD11b, CD11c, CD18, CD44, CD49d and CD62L by peripheral blood eosinophils was examined by flow cytometry [6].
• Trichostrongylus colubriformis extract upregulates TNF-alpha receptor expression and enhances TNF-alpha sensitivity of L929 cells [7].

Biological context of Trichostrongylus

• The candidate gene tar-1 (for Trichostrongylus acetylcholine receptor subunit gene 1) comprising 13704 base pairs was thus identified [4].
• Antibody responses of sheep to challenge with Trichostrongylus colubriformis and the effect of dexamethasone treatment [8].
• The nicotinic acetylcholine alpha-subunit gene tar-1 is located on the X chromosome but its coding sequence is not involved in levamisole resistance in an isolate of Trichostrongylus colubriformis [9].
• The influence of Ostertagia circumcincta and Trichostrongylus colubriformis infections on the pharmacokinetics of febantel in lambs [10].

Anatomical context of Trichostrongylus

• The effect of continuous doses of Trichostrongylus colubriformis larvae on the intestinal mucosa of sheep and on liver vitamin A concentration [11].
• The parasitic nematodes, Ascaridia galli and Trichostrongylus colubriformis, were prepared for electron microscopy with fixatives containing tannic acid, which allowed their microtubule protofilament number to be examined [12].
• Subclinical infection with the nematode Trichostrongylus colubriformis increases gastrointestinal tract leucine metabolism and reduces availability of leucine for other tissues [13].
• Luxabendazole at 7.5, 10.0, and 12.5 mg/kg proved 100% effective in removing adult worms of the genera Haemonchus, Ostertagia, Trichostrongylus, Cooperia and Nematodirus as well as tissue-associated larval stages of gastrointestinal nematodes of the abomasal mucosa [14].
• Studies on the role of histamine and 5-hydroxytryptamine in immunity against the nematode Trichostrongylus colubriformis. IV. Inhibition of the expulsion of worms transplanted into the duodenum of immune guinea pigs [15].

Associations of Trichostrongylus with chemical compounds

• Beta-tubulin gene polymorphism and benzimidazole resistance in trichostrongylus colubriformis [16].
• Levamisole resistance in Trichostrongylus colubriformis: a sex-linked recessive character [17].
• The inheritance of thiabendazole resistance in Trichostrongylus colubriformis [18].
• The effect of reduced feed intake on the efficacy of oxfendazole against benzimidazole resistant Haemonchus contortus and Trichostrongylus colubriformis in sheep [19].
• Histamine and leukotriene concentrations in duodenal tissue and mucus of lambs selected for high and low responsiveness to vaccination and challenge with Trichostrongylus colubriformis [20].

Gene context of Trichostrongylus

• Characterization of cDNA clones coding for muscle tropomyosin of the nematode Trichostrongylus colubriformis [21].
• Vaccination against the nematode Trichostrongylus colubriformis. II. Attempts to protect guinea-pigs with worm acetylcholinesterase [22].
• Temperature dependent binding of mebendazole to tubulin in benzimidazole-susceptible and -resistant strains of Trichostrongylus colubriformis and Caenorhabditis elegans [23].
• Characterization of the mRNA encoding a proline-rich 37-kilodalton glycoprotein from the excretory-secretory products of Trichostrongylus colubriformis [24].
• Trichostrongylus colubriformis: analysis of monoclonal antibody and lectin binding to the larval cuticle [25].

Analytical, diagnostic and therapeutic context of Trichostrongylus

• Serum levels of specific antibodies to excretory/secretory antigens of the third larval stage (L3) of Cooperia curticei, Ostertagia circumcincta or Trichostrongylus colubriformis and somatic antigens from adult T. colubriformis were determined at monthly intervals by ELISA [26].
• Testosterone, progesterone and cholesterol were found in mixed sexes of the nematode Trichostrongylus colubriformis from goats, according to thin-layer, gas-liquid and high-performance liquid chromatography [27].
• 1. Radiolabeled epinephrine, norepinephrine, octopamine and histamine were introduced into homogenates of mixed sexes of the nematode Trichostrongylus colubriformis and the labeled derivatives formed during incubation were identified by HPLC [28].

References