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Disease relevance of Trichostrongylus

  • Treatment with closantel (7.5 mg/kg) at the same times was very effective against H. contortus but ineffective against Trichostrongylus spp; 25% of lambs had to be withdrawn because of severe trichostrongylosis [1].
  • AIMS: To determine the efficacy of eprinomectin, doramectin and a combination of albendazole and levamisole in suppressing or eliminating nematode infections or faecal egg counts (FEC) in possums naturally or experimentally infected with Parastrongyloides trichosuri, Paraustrostrongylus trichosuri and Trichostrongylus colubriformis [2].

High impact information on Trichostrongylus

  • Experiments on red grouse Lagopus lagopus scoticus have shown that population instability can be caused both by the effects of a parasitic nematode, Trichostrongylus tenuis, on host production or by changes in testosterone influencing aggressive behaviour and recruitment [3].
  • Cloning and sequence analysis of the candidate nicotinic acetylcholine receptor alpha subunit gene tar-1 from Trichostrongylus colubriformis [4].
  • Identification and characterisation of an aspartyl protease inhibitor homologue as a major allergen of Trichostrongylus colubriformis [5].
  • The effect of infection of sheep with the gastrointestinal nematode parasite Trichostrongylus colubriformis on expression of adhesion molecules CD11a, CD11b, CD11c, CD18, CD44, CD49d and CD62L by peripheral blood eosinophils was examined by flow cytometry [6].
  • Trichostrongylus colubriformis extract upregulates TNF-alpha receptor expression and enhances TNF-alpha sensitivity of L929 cells [7].

Biological context of Trichostrongylus


Anatomical context of Trichostrongylus


Associations of Trichostrongylus with chemical compounds


Gene context of Trichostrongylus


Analytical, diagnostic and therapeutic context of Trichostrongylus


  1. Control of helminthosis in lambs by strategic treatment with closantel and broad-spectrum anthelmintics. Dash, K.M. Aust. Vet. J. (1986) [Pubmed]
  2. Anthelmintics for the control of nematode infections in the brushtail possum (Trichosurus vulpecula). Ralston, M.J., Stankiewicz, M., Heath, D.D. New Zealand veterinary journal. (2001) [Pubmed]
  3. Interactions between intrinsic and extrinsic mechanisms in a cyclic species: testosterone increases parasite infection in red grouse. Seivwright, L.J., Redpath, S.M., Mougeot, F., Leckie, F., Hudson, P.J. Proc. Biol. Sci. (2005) [Pubmed]
  4. Cloning and sequence analysis of the candidate nicotinic acetylcholine receptor alpha subunit gene tar-1 from Trichostrongylus colubriformis. Wiley, L.J., Weiss, A.S., Sangster, N.C., Li, Q. Gene (1996) [Pubmed]
  5. Identification and characterisation of an aspartyl protease inhibitor homologue as a major allergen of Trichostrongylus colubriformis. Shaw, R.J., McNeill, M.M., Maass, D.R., Hein, W.R., Barber, T.K., Wheeler, M., Morris, C.A., Shoemaker, C.B. Int. J. Parasitol. (2003) [Pubmed]
  6. Expression of cell surface adhesion molecules by peripheral blood eosinophils during Trichostrongylus colubriformis infection in sheep. Stevenson, L.M., Colditz, I.G., Lejambre, L.F. Immunol. Cell Biol. (2001) [Pubmed]
  7. Trichostrongylus colubriformis extract upregulates TNF-alpha receptor expression and enhances TNF-alpha sensitivity of L929 cells. Riffkin, M.C., Seow, H.F., Wood, P.R., Brown, L.E., Jackson, D.C., Scheerlinck, J.P. Immunol. Cell Biol. (2000) [Pubmed]
  8. Antibody responses of sheep to challenge with Trichostrongylus colubriformis and the effect of dexamethasone treatment. Douch, P.G., Green, R.S., Risdon, P.L. Int. J. Parasitol. (1994) [Pubmed]
  9. The nicotinic acetylcholine alpha-subunit gene tar-1 is located on the X chromosome but its coding sequence is not involved in levamisole resistance in an isolate of Trichostrongylus colubriformis. Wiley, L.J., Ferrara, D.R., Sangster, N.C., Weiss, A.S. Mol. Biochem. Parasitol. (1997) [Pubmed]
  10. The influence of Ostertagia circumcincta and Trichostrongylus colubriformis infections on the pharmacokinetics of febantel in lambs. Debackere, M., Landuyt, J., Vercruysse, J., McKellar, Q. J. Vet. Pharmacol. Ther. (1993) [Pubmed]
  11. The effect of continuous doses of Trichostrongylus colubriformis larvae on the intestinal mucosa of sheep and on liver vitamin A concentration. Coop, R.L., Angus, K.W. Parasitology (1975) [Pubmed]
  12. Protofilament number in microtubules in cells of two parasitic nematodes. Davis, C., Gull, K. J. Parasitol. (1983) [Pubmed]
  13. Subclinical infection with the nematode Trichostrongylus colubriformis increases gastrointestinal tract leucine metabolism and reduces availability of leucine for other tissues. Yu, F., Bruce, L.A., Calder, A.G., Milne, E., Coop, R.L., Jackson, F., Horgan, G.W., MacRae, J.C. J. Anim. Sci. (2000) [Pubmed]
  14. Activity of luxabendazole against liver flukes, gastrointestinal roundworms, and lungworms in naturally infected sheep. Kassai, T., Takáts, C., Fok, E., Redl, P. Parasitol. Res. (1988) [Pubmed]
  15. Studies on the role of histamine and 5-hydroxytryptamine in immunity against the nematode Trichostrongylus colubriformis. IV. Inhibition of the expulsion of worms transplanted into the duodenum of immune guinea pigs. Rothwell, T.L., Love, R.J., Evans, D.P. Int. Arch. Allergy Appl. Immunol. (1978) [Pubmed]
  16. Beta-tubulin gene polymorphism and benzimidazole resistance in trichostrongylus colubriformis. Grant, W.N., Mascord, L.J. Int. J. Parasitol. (1996) [Pubmed]
  17. Levamisole resistance in Trichostrongylus colubriformis: a sex-linked recessive character. Martin, P.J., McKenzie, J.A. Int. J. Parasitol. (1990) [Pubmed]
  18. The inheritance of thiabendazole resistance in Trichostrongylus colubriformis. Martin, P.J., McKenzie, J.A., Stone, R.A. Int. J. Parasitol. (1988) [Pubmed]
  19. The effect of reduced feed intake on the efficacy of oxfendazole against benzimidazole resistant Haemonchus contortus and Trichostrongylus colubriformis in sheep. Ali, D.N., Hennessy, D.R. Int. J. Parasitol. (1995) [Pubmed]
  20. Histamine and leukotriene concentrations in duodenal tissue and mucus of lambs selected for high and low responsiveness to vaccination and challenge with Trichostrongylus colubriformis. Jones, W.O., Window, R.G., Steel, J.W., Outteridge, P.M. Int. J. Parasitol. (1990) [Pubmed]
  21. Characterization of cDNA clones coding for muscle tropomyosin of the nematode Trichostrongylus colubriformis. Frenkel, M.J., Savin, K.W., Bakker, R.E., Ward, C.W. Mol. Biochem. Parasitol. (1989) [Pubmed]
  22. Vaccination against the nematode Trichostrongylus colubriformis. II. Attempts to protect guinea-pigs with worm acetylcholinesterase. Rothwell, T.L., Merritt, G.C. Int. J. Parasitol. (1975) [Pubmed]
  23. Temperature dependent binding of mebendazole to tubulin in benzimidazole-susceptible and -resistant strains of Trichostrongylus colubriformis and Caenorhabditis elegans. Russell, G.J., Lacey, E. Int. J. Parasitol. (1991) [Pubmed]
  24. Characterization of the mRNA encoding a proline-rich 37-kilodalton glycoprotein from the excretory-secretory products of Trichostrongylus colubriformis. Verkuylen, A.J., Frenkel, M.J., Savin, K.W., Dopheide, T.A., Ward, C.W. Mol. Biochem. Parasitol. (1993) [Pubmed]
  25. Trichostrongylus colubriformis: analysis of monoclonal antibody and lectin binding to the larval cuticle. Milner, A.R., Mack, W.N. Parasite Immunol. (1988) [Pubmed]
  26. Antibody responses of grazing alpacas (Lama pacos) in New Zealand to intestinal nematodes. Green, R.S., Douch, P.G., Hill, F.I., Death, A.F., Wyeth, T.K., Donaghy, M.J. Int. J. Parasitol. (1996) [Pubmed]
  27. Sex steroid content and metabolism in Trichostrongylus colubriformis (Nematoda). Chung, W.L., Parish, E.J., Bone, L.W. J. Parasitol. (1986) [Pubmed]
  28. Derivatives of epinephrine, norepinephrine, octopamine and histamine formed by homogenates of Trichostrongylus colubriformis, a nematode parasite of ruminants. Frandsen, J.C., Bone, L.W. Comp. Biochem. Physiol. C, Comp. Pharmacol. Toxicol. (1988) [Pubmed]
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