Disease relevance of mshi

• Molecular genetic mapping of the mouse male sterility and histoincompatibility (mshi) mutation on proximal chromosome 10 [1].
• Male sterility and histoincompatibility, mshi, is an autosomal recessive mutation in BALB/cBy mice that causes reduced testis size and sterility in homozygous males [2].

High impact information on mshi

• The recessive male sterility and histoincompatibility (mshi) mutation in the mouse generates pleiotropic effects on histocompatibility and male reproduction, while female mutants appear to be reproductively normal [1].
• We have mapped the mshi mutation to mouse Chromosome (Chr) 10 by analysis of 126 progeny from an intraspecific backcross [1].
• Mouse male sterility and histoincompatibility (mshi) maps between the D10Mit51/168/212 cluster and D10Mit213 [3].
• Here we present the microsatellite polymorphism analysis of a new 276-member intraspecific backcross panel--including a set of 135 males typed for sterility and histoincompatibility--that places both features controlled by mshi within a 1.7-cM interval between markers D10Mit51/168/212 and D10Mit213 [3].
• In addition, this analysis has allowed an explicit test of a two-gene model for the mshi locus and has provided a measurement of the penetrance of the mshi-generated histogenic phenotype in both male (88.4 +/- 3.9%) and female (91.0 +/- 3.5%) mutants [3].

Regulatory relationships of mshi

• In addition to generating sterility in homozygous males, mshi controls the loss of a minor histocompatibility antigen designated H-mshi [4].

Analytical, diagnostic and therapeutic context of mshi

• Previous analysis of backcross mice typed for mshi either by testicular morphology or by allograft rejection has located each trait to a 20-cM region on proximal mouse Chr 10 [3].
• The recessive male sterility and histoincompatibility (mshi) mutation in the mouse generates pleiotropic effects on graft transplantation and male reproduction [3].

References