Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

mt-Nd6 - NADH dehydrogenase 6, mitochondrial

Mus musculus

Synonyms: AA435281, AU018494, AU018568, AU019189, AU019781, ...

Bhat, K.S. et al., Shan, B. et al., Bai, Y. et al.

Bai, Hu, Park, Deng, Song, Chomyn, Yagi, Attardi,

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High impact information on mt-Nd6

A further cDNA encompassing three mitochondrial genes was used as a probe to show that a third mRNA, NADH dehydrogenase subunit 5, was also down-regulated by interferon while a fourth, NADH dehydrogenase subunit 6, was unaffected [1].
The nature of RNA coded by the only light-strand (L-strand) open-reading frame unidentified reading frame 6 (URF6) was studied by using a variety of single- and double-strand DNA subclones derived from the 3.6-kilobase (kb) cytochrome b (cyt b)-URF5 coding region of the mouse mitochondrial genome [2].
The S1 nuclease protection experiments using both the 3'- or 5'-end-labeled DNA probes and also affinity-purified 32P-labeled RNA probes indicate that the 1.15-kb RNA maps between the start of the URF6 reading frame (3' end) and a region 590-600 nucleotides to the 5' end of this reading frame [2].

Anatomical context of mt-Nd6

With this method, 15 mouse cell lines with deficiencies in complex I-dependent respiration were obtained, and two near-homoplasmic mutations in mouse ND5 and ND6 genes were isolated [3].

References

Interferon selectively inhibits the expression of mitochondrial genes: a novel pathway for interferon-mediated responses. Shan, B., Vazquez, E., Lewis, J.A. EMBO J. (1990) [Pubmed]
Expression of the cytochrome b-URF6-URF5 region of the mouse mitochondrial genome. Bhat, K.S., Bhat, N.K., Kulkarni, G.R., Iyengar, A., Avadhani, N.G. Biochemistry (1985) [Pubmed]
Genetic and functional analysis of mitochondrial DNA-encoded complex I genes. Bai, Y., Hu, P., Park, J.S., Deng, J.H., Song, X., Chomyn, A., Yagi, T., Attardi, G. Ann. N. Y. Acad. Sci. (2004) [Pubmed]

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