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Gene Review:

him-3 - Protein HIM-3

Caenorhabditis elegans

Zetka, M.C. et al., Couteau, F. et al., Couteau, F. et al.

Zetka, Kawasaki, Strome, Müller,

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High impact information on him-3

In the present study, we find that two closely related members of the him-3 gene family in Caenorhabditis elegans function as regulators of synapsis [1].
We have isolated a Caenorhabditis elegans gene, him-3, which encodes a meiosis-specific component of chromosome cores with some similarity to the yeast lateral element protein Hop1p [2].
Hypomorphs of him-3, although being synapsis proficient, show severe reductions in the frequency of crossing-over, demonstrating that HIM-3 has a role in establishing normal levels of interhomolog exchange [2].
Surprisingly, RAD-51-marked recombination intermediates disappear with apparent wild-type kinetics in him-3 null mutants in which homologs are spatially unavailable for recombination, raising the possibility that HIM-3's presence at chromosome axes inhibits the use of sister chromatids as templates for repair [3].

References

HTP-1 coordinates synaptonemal complex assembly with homolog alignment during meiosis in C. elegans. Couteau, F., Zetka, M. Genes Dev. (2005) [Pubmed]
Synapsis and chiasma formation in Caenorhabditis elegans require HIM-3, a meiotic chromosome core component that functions in chromosome segregation. Zetka, M.C., Kawasaki, I., Strome, S., Müller, F. Genes Dev. (1999) [Pubmed]
A component of C. elegans meiotic chromosome axes at the interface of homolog alignment, synapsis, nuclear reorganization, and recombination. Couteau, F., Nabeshima, K., Villeneuve, A., Zetka, M. Curr. Biol. (2004) [Pubmed]

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