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epi-1  -  Protein EPI-1

Caenorhabditis elegans

 
 
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High impact information on laminin

  • This is a large complex protein with regions similar to low-density lipoprotein receptors, laminin, and neural cell adhesion molecules (NCAMs) [1].
  • The role of the laminin beta subunit in laminin heterotrimer assembly and basement membrane function and development in C. elegans [2].
  • Furthermore, a distinctive set of phenotypes is caused by both viable laminin alpha and beta partial loss-of-function mutations [2].
  • Netrins, a family of laminin-related secreted proteins, have critical roles in axon guidance and cell migration during development [3].

References

  1. Complex patterns of alternative splicing mediate the spatial and temporal distribution of perlecan/UNC-52 in Caenorhabditis elegans. Mullen, G.P., Rogalski, T.M., Bush, J.A., Gorji, P.R., Moerman, D.G. Mol. Biol. Cell (1999) [Pubmed]
  2. The role of the laminin beta subunit in laminin heterotrimer assembly and basement membrane function and development in C. elegans. Kao, G., Huang, C.C., Hedgecock, E.M., Hall, D.H., Wadsworth, W.G. Dev. Biol. (2006) [Pubmed]
  3. Netrin-1: interaction with deleted in colorectal cancer (DCC) and alterations in brain tumors and neuroblastomas. Meyerhardt, J.A., Caca, K., Eckstrand, B.C., Hu, G., Lengauer, C., Banavali, S., Look, A.T., Fearon, E.R. Cell Growth Differ. (1999) [Pubmed]
 
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