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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

LAMA5  -  laminin, alpha 5

Homo sapiens

Synonyms: KIAA0533, KIAA1907, Laminin subunit alpha-5, Laminin-10 subunit alpha, Laminin-11 subunit alpha, ...
 
 
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High impact information on LAMA5

  • Lama5 -/- skin showed defective basement membrane assembly, without measurable increases in anoikis [1].
  • E16.5 Lama5 -/- mouse skin, lacking laminin-10, contained fewer hair germs compared with controls, and after transplantation, Lama5 -/- skin showed a failure of hair germ elongation followed by complete hair follicle regression [1].
  • The human laminin alpha5-chain gene (LAMA5) was assigned to chromosome 20q13.2-q13.3 by in situ hybridization, and the mouse gene (Lama5) was mapped by linkage analysis to a syntonic region of distal chromosome 2, close to the locus for the ragged (Ra) mutation [2].

References

  1. Laminin-10 is crucial for hair morphogenesis. Li, J., Tzu, J., Chen, Y., Zhang, Y.P., Nguyen, N.T., Gao, J., Bradley, M., Keene, D.R., Oro, A.E., Miner, J.H., Marinkovich, M.P. EMBO J. (2003) [Pubmed]
  2. Tissue-specific expression of the human laminin alpha5-chain, and mapping of the gene to human chromosome 20q13.2-13.3 and to distal mouse chromosome 2 near the locus for the ragged (Ra) mutation. Durkin, M.E., Loechel, F., Mattei, M.G., Gilpin, B.J., Albrechtsen, R., Wewer, U.M. FEBS Lett. (1997) [Pubmed]
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