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Gene Review

Lama5  -  laminin, alpha 5

Mus musculus

Synonyms: AA408760, AA408762, AI853660, Laminin subunit alpha-5, Laminin-10 subunit alpha, ...
 
 
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Disease relevance of Lama5

 

High impact information on Lama5

  • Lama5-null mice develop a small tooth germ with defective cusp formation and have reduced proliferation of dental epithelium [2].
  • Here, we have examined the role of laminin alpha5 (Lama5) in tooth development using laminin alpha5-null mouse primary dental epithelium and tooth germ organ cultures [2].
  • A new mouse PKD model has been produced through insertion of a PGKneo cassette in an intron of the gene that encodes laminin alpha5 (Lama5), a major tubular and glomerular basement membrane component that is important for glomerulogenesis and ureteric bud branching [3].
  • Crossing the transgenes onto the Lama5-/- background generates "pseudo-knockins", so called because endogenous laminin alpha5 is replaced by transgene-encoded proteins [4].
  • The mouse laminin alpha5 chain gene (Lama5) has been mapped close to the locus of the semidominant ragged (Ra) mutation on distal chromosome 2 [5].
 

Associations of Lama5 with chemical compounds

  • Inhibition of laminin-511 receptor beta1 integrin disrupted DP primary cilia formation as well as hair development [6].

References

  1. Laminin alpha 5 is required for lobar septation and visceral pleural basement membrane formation in the developing mouse lung. Nguyen, N.M., Miner, J.H., Pierce, R.A., Senior, R.M. Dev. Biol. (2002) [Pubmed]
  2. Laminin alpha5 is required for dental epithelium growth and polarity and the development of tooth bud and shape. Fukumoto, S., Miner, J.H., Ida, H., Fukumoto, E., Yuasa, K., Miyazaki, H., Hoffman, M.P., Yamada, Y. J. Biol. Chem. (2006) [Pubmed]
  3. A Hypomorphic Mutation in the Mouse Laminin {alpha}5 Gene Causes Polycystic Kidney Disease. Shannon, M.B., Patton, B.L., Harvey, S.J., Miner, J.H. J. Am. Soc. Nephrol. (2006) [Pubmed]
  4. Molecular dissection of laminin alpha 5 in vivo reveals separable domain-specific roles in embryonic development and kidney function. Kikkawa, Y., Miner, J.H. Dev. Biol. (2006) [Pubmed]
  5. Evaluation of Lama5 as a candidate for the mouse ragged (Ra) mutation. Durkin, M.E., Albrechtsen, R., Chambers, D.M., Abbott, C.M., Wewer, U.M. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
  6. Laminin-511 is an epithelial message promoting dermal papilla development and function during early hair morphogenesis. Gao, J., DeRouen, M.C., Chen, C.H., Nguyen, M., Nguyen, N.T., Ido, H., Harada, K., Sekiguchi, K., Morgan, B.A., Miner, J.H., Oro, A.E., Marinkovich, M.P. Genes Dev. (2008) [Pubmed]
 
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