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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

unc-30  -  Protein UNC-30

Caenorhabditis elegans

 
 
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High impact information on unc-30

  • Ectopic expression of unc-30 induced GABA expression in cells that are normally not GABAergic [1].
  • The Caenorhabditis elegans gene unc-30 is required for the development and functioning of the 19 inhibitory GABAergic (gamma-aminobutyric-acid-secreting) type D motor neurons, which control locomotion [1].
  • Finally, the expression patterns of three neuronal type-specific transcription factors, unc-3, unc-4 and unc-30, were altered [2].
  • Previously, we have identified that the unc-30 homeobox gene controls the fate of 19 type D GABAergic neurons [3].
  • Expression of bar-1 from the 321-bp element rescued the Uncoordinated (Unc) phenotype of bar-1 mutants, but not the vulval phenotype, suggesting that a Wnt pathway may act in ventral cord neurons to mediate proper locomotion [4].
 

Biological context of unc-30

  • Pitx2 rescues the GABAergic differentiation defect and partially rescues the axon guidance and behavioral phenotypes of unc-30 mutants, indicating a high degree of functional conservation between these evolutionarily related genes [5].
 

Anatomical context of unc-30

  • The gene unc-30 is required for the differentiation of a specific type of GABAergic neuron, the type-D inhibitory motor neuron [6].

References

  1. Control of type-D GABAergic neuron differentiation by C. elegans UNC-30 homeodomain protein. Jin, Y., Hoskins, R., Horvitz, H.R. Nature (1994) [Pubmed]
  2. The C. elegans NeuroD homolog cnd-1 functions in multiple aspects of motor neuron fate specification. Hallam, S., Singer, E., Waring, D., Jin, Y. Development (2000) [Pubmed]
  3. Coordinated transcriptional regulation of the unc-25 glutamic acid decarboxylase and the unc-47 GABA vesicular transporter by the Caenorhabditis elegans UNC-30 homeodomain protein. Eastman, C., Horvitz, H.R., Jin, Y. J. Neurosci. (1999) [Pubmed]
  4. Identification of evolutionarily conserved promoter elements and amino acids required for function of the C. elegans beta-catenin homolog BAR-1. Natarajan, L., Jackson, B.M., Szyleyko, E., Eisenmann, D.M. Dev. Biol. (2004) [Pubmed]
  5. Conserved function of Caenorhabditis elegans UNC-30 and mouse Pitx2 in controlling GABAergic neuron differentiation. Westmoreland, J.J., McEwen, J., Moore, B.A., Jin, Y., Condie, B.G. J. Neurosci. (2001) [Pubmed]
  6. Genes required for GABA function in Caenorhabditis elegans. McIntire, S.L., Jorgensen, E., Horvitz, H.R. Nature (1993) [Pubmed]
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