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Gene Review

pos-1  -  Protein POS-1

Caenorhabditis elegans

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High impact information on pos-1

  • The earliest defect detected in pos-1 mutants is the failure to express APX-1 protein from maternally provided apx-1 mRNA, suggesting that POS-1 may have an important role in regulating the expression of maternal mRNAs in germline blastomeres [1].
  • During early embryogenesis, pos-1 mRNA and POS-1 protein are present predominantly in the germ precursors [1].
  • pos-1 encodes a cytoplasmic zinc-finger protein essential for germline specification in C. elegans [1].
  • We show that maternal-effect lethal mutations in the gene pos-1 cause germ cell precursors to inappropriately adopt somatic cell fates [1].
  • We find that the pos-1 RNA is expressed in the hermaphrodite and female gonads of C. briggsae and C. remanei but POS-1 protein is not detected at high levels in C. briggsae until the 2-cell stage of embryogenesis [2].


  1. pos-1 encodes a cytoplasmic zinc-finger protein essential for germline specification in C. elegans. Tabara, H., Hill, R.J., Mello, C.C., Priess, J.R., Kohara, Y. Development (1999) [Pubmed]
  2. Cloning and expression analysis of pos-1 in the nematodes Caenorhabditis briggsae and Caenorhabditis remanei. Konwerski, J., Senchuk, M., Petty, E., Lahaie, D., Schisa, J.A. Dev. Dyn. (2005) [Pubmed]
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