The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

egl-9  -  Protein EGL-9

Caenorhabditis elegans

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of egl-9

  • Null mutants in egl-9 result in a complete tolerance to an otherwise lethal toxin produced by Pseudomonas aeruginosa [1].
  • In contrast, the hif-1 (hypoxia inducible factor) loss-of-function strain did not show acclimation, and non-acclimated vhl-1 and egl-9 mutants (overexpressing HIF-1) had greater heat endurance than the wild type [2].

High impact information on egl-9

  • Finally, several C. elegans genes, including hif-1 and egl-9, rendered C. elegans less susceptible to EPEC when mutated, suggesting their involvement in mediating toxin effects [3].
  • First, the expression of HIF-1 target genes is markedly higher in egl-9 mutants than in vhl-1 mutants [4].
  • Rat Sm-20 is a homologue of the Caenorhabditis elegans gene egl-9 and has been implicated in the regulation of growth, differentiation and apoptosis in muscle and nerve cells [1].


  1. Characterization and comparative analysis of the EGLN gene family. Taylor, M.S. Gene (2001) [Pubmed]
  2. HIF-1 is required for heat acclimation in the nematode Caenorhabditis elegans. Treinin, M., Shliar, J., Jiang, H., Powell-Coffman, J.A., Bromberg, Z., Horowitz, M. Physiol. Genomics (2003) [Pubmed]
  3. Paralysis and killing of Caenorhabditis elegans by enteropathogenic Escherichia coli requires the bacterial tryptophanase gene. Anyanful, A., Dolan-Livengood, J.M., Lewis, T., Sheth, S., Dezalia, M.N., Sherman, M.A., Kalman, L.V., Benian, G.M., Kalman, D. Mol. Microbiol. (2005) [Pubmed]
  4. The Caenorhabditis elegans rhy-1 Gene Inhibits HIF-1 Hypoxia-Inducible Factor Activity in a Negative Feedback Loop That Does Not Include vhl-1. Shen, C., Shao, Z., Powell-Coffman, J.A. Genetics (2006) [Pubmed]
WikiGenes - Universities