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Gene Review:

egl-9 - Protein EGL-9

Caenorhabditis elegans

Taylor, M.S., Treinin, M. et al., Anyanful, A. et al., Shen, C. et al.

Taylor,

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Disease relevance of egl-9

Null mutants in egl-9 result in a complete tolerance to an otherwise lethal toxin produced by Pseudomonas aeruginosa [1].
In contrast, the hif-1 (hypoxia inducible factor) loss-of-function strain did not show acclimation, and non-acclimated vhl-1 and egl-9 mutants (overexpressing HIF-1) had greater heat endurance than the wild type [2].

High impact information on egl-9

Finally, several C. elegans genes, including hif-1 and egl-9, rendered C. elegans less susceptible to EPEC when mutated, suggesting their involvement in mediating toxin effects [3].
First, the expression of HIF-1 target genes is markedly higher in egl-9 mutants than in vhl-1 mutants [4].
Rat Sm-20 is a homologue of the Caenorhabditis elegans gene egl-9 and has been implicated in the regulation of growth, differentiation and apoptosis in muscle and nerve cells [1].

References

Characterization and comparative analysis of the EGLN gene family. Taylor, M.S. Gene (2001) [Pubmed]
HIF-1 is required for heat acclimation in the nematode Caenorhabditis elegans. Treinin, M., Shliar, J., Jiang, H., Powell-Coffman, J.A., Bromberg, Z., Horowitz, M. Physiol. Genomics (2003) [Pubmed]
Paralysis and killing of Caenorhabditis elegans by enteropathogenic Escherichia coli requires the bacterial tryptophanase gene. Anyanful, A., Dolan-Livengood, J.M., Lewis, T., Sheth, S., Dezalia, M.N., Sherman, M.A., Kalman, L.V., Benian, G.M., Kalman, D. Mol. Microbiol. (2005) [Pubmed]
The Caenorhabditis elegans rhy-1 Gene Inhibits HIF-1 Hypoxia-Inducible Factor Activity in a Negative Feedback Loop That Does Not Include vhl-1. Shen, C., Shao, Z., Powell-Coffman, J.A. Genetics (2006) [Pubmed]

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