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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Nap1l2  -  nucleosome assembly protein 1-like 2

Mus musculus

Synonyms: Bpx, Brain-specific protein, X-linked, Nucleosome assembly protein 1-like 2
 
 
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High impact information on Nap1l2

  • Protein expression studies showed that the Nap1l2 protein binds to condensing chromatin during S phase and in apoptotic cells, but remained cytoplasmic during G1 phase [1].
  • Nap1l2 therefore likely represents a class of tissue-specific factors interacting with chromatin to regulate neuronal cell proliferation [1].
  • The X-linked gene Nap1l2, specifically expressed in neurons, encodes a protein that is highly similar to the nucleosome assembly (NAP) and SET proteins [1].
  • We have cloned and characterized a new gene, Bpx, lying distal to the murine Xist [2].
  • Cloning and characterization of a murine brain specific gene Bpx and its human homologue lying within the Xic candidate region [2].
 

Analytical, diagnostic and therapeutic context of Nap1l2

References

  1. Control of neurulation by the nucleosome assembly protein-1-like 2. Rogner, U.C., Spyropoulos, D.D., Le Novère, N., Changeux, J.P., Avner, P. Nat. Genet. (2000) [Pubmed]
  2. Cloning and characterization of a murine brain specific gene Bpx and its human homologue lying within the Xic candidate region. Rougeulle, C., Avner, P. Hum. Mol. Genet. (1996) [Pubmed]
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