Gene Review:
Xist - inactive X specific transcripts
Mus musculus
Synonyms:
A430022B11, AI314753
- Praja1, a novel gene encoding a RING-H2 motif in mouse development. Mishra, L., Tully, R.E., Monga, S.P., Yu, P., Cai, T., Makalowski, W., Mezey, E., Pavan, W.J., Mishra, B. Oncogene (1997)
- Xist is expressed in female embryonal carcinoma cells with two active X chromosomes. Tai, H.H., Gordon, J., McBurney, M.W. Somat. Cell Mol. Genet. (1994)
- Homozygous Tsix mutant mice reveal a sex-ratio distortion and revert to random X-inactivation. Lee, J.T. Nat. Genet. (2002)
- Chromosomal silencing and localization are mediated by different domains of Xist RNA. Wutz, A., Rasmussen, T.P., Jaenisch, R. Nat. Genet. (2002)
- Aberrant patterns of X chromosome inactivation in bovine clones. Xue, F., Tian, X.C., Du, F., Kubota, C., Taneja, M., Dinnyes, A., Dai, Y., Levine, H., Pereira, L.V., Yang, X. Nat. Genet. (2002)
- Expression of Xist during mouse development suggests a role in the initiation of X chromosome inactivation. Kay, G.F., Penny, G.D., Patel, D., Ashworth, A., Brockdorff, N., Rastan, S. Cell (1993)
- Skewing X chromosome choice by modulating sense transcription across the Xist locus. Nesterova, T.B., Johnston, C.M., Appanah, R., Newall, A.E., Godwin, J., Alexiou, M., Brockdorff, N. Genes Dev. (2003)
- Xce haplotypes show modified methylation in a region of the active X chromosome lying 3' to Xist. Courtier, B., Heard, E., Avner, P. Proc. Natl. Acad. Sci. U.S.A. (1995)
- Functional analysis of the DXPas34 locus, a 3' regulator of Xist expression. Debrand, E., Chureau, C., Arnaud, D., Avner, P., Heard, E. Mol. Cell. Biol. (1999)
- Quantitative RT-PCR assays show Xist RNA levels are low in mouse female adult tissue, embryos and embryoid bodies. Buzin, C.H., Mann, J.R., Singer-Sam, J. Development (1994)
- Expression of X-linked genes in androgenetic, gynogenetic, and normal mouse preimplantation embryos. Latham, K.E., Rambhatla, L. Dev. Genet. (1995)
- Xist has properties of the X-chromosome inactivation centre. Herzing, L.B., Romer, J.T., Horn, J.M., Ashworth, A. Nature (1997)
- A 94 kb genomic sequence 3' to the murine Xist gene reveals an AT rich region containing a new testis specific gene Tsx. Simmler, M.C., Cunningham, D.B., Clerc, P., Vermat, T., Caudron, B., Cruaud, C., Pawlak, A., Szpirer, C., Weissenbach, J., Claverie, J.M., Avner, P. Hum. Mol. Genet. (1996)
- Methylation of histone H3 at Lys-9 is an early mark on the X chromosome during X inactivation. Heard, E., Rougeulle, C., Arnaud, D., Avner, P., Allis, C.D., Spector, D.L. Cell (2001)
- Gamete-specific methylation correlates with imprinting of the murine Xist gene. Ariel, M., Robinson, E., McCarrey, J.R., Cedar, H. Nat. Genet. (1995)
- Synergism of Xist RNA, DNA methylation, and histone hypoacetylation in maintaining X chromosome inactivation. Csankovszki, G., Nagy, A., Jaenisch, R. J. Cell Biol. (2001)
- In vivo ultraviolet and dimethyl sulfate footprinting of the 5' region of the expressed and silent Xist alleles. Komura, J., Sheardown, S.A., Brockdorff, N., Singer-Sam, J., Riggs, A.D. J. Biol. Chem. (1997)
- Methylation status of CpG sites and methyl-CpG binding proteins are involved in the promoter regulation of the mouse Xist gene. Allaman-Pillet, N., Djemaï, A., Bonny, C., Schorderet, D.F. Gene Expr. (1998)
- Mbd2 contributes to DNA methylation-directed repression of the Xist gene. Barr, H., Hermann, A., Berger, J., Tsai, H.H., Adie, K., Prokhortchouk, A., Hendrich, B., Bird, A. Mol. Cell. Biol. (2007)
- A transient heterochromatic state in Xist preempts X inactivation choice without RNA stabilization. Sun, B.K., Deaton, A.M., Lee, J.T. Mol. Cell (2006)
- Xite, X-inactivation intergenic transcription elements that regulate the probability of choice. Ogawa, Y., Lee, J.T. Mol. Cell (2003)
- Compact chromatin packaging of inactive X chromosome involves the actively transcribed Xist gene. Endo, Y., Watanabe, T., Mishima, Y., Yoshimura, A., Takagi, N., Kominami, R. Mamm. Genome (1999)
- De novo DNA methylation is dispensable for the initiation and propagation of X chromosome inactivation. Sado, T., Okano, M., Li, E., Sasaki, H. Development (2004)
- Mouse Xist expression begins at zygotic genome activation and is timed by a zygotic clock. Zuccotti, M., Boiani, M., Ponce, R., Guizzardi, S., Scandroglio, R., Garagna, S., Redi, C.A. Mol. Reprod. Dev. (2002)
- Chromatin structure analysis of the mouse Xist locus. McCabe, V., Formstone, E.J., O'Neill, L.P., Turner, B.M., Brockdorff, N. Proc. Natl. Acad. Sci. U.S.A. (1999)
- Comparison of gene expression in male and female mouse blastocysts revealed imprinting of the X-linked gene, Rhox5/Pem, at preimplantation stages. Kobayashi, S., Isotani, A., Mise, N., Yamamoto, M., Fujihara, Y., Kaseda, K., Nakanishi, T., Ikawa, M., Hamada, H., Abe, K., Okabe, M. Curr. Biol. (2006)
- Characterization of mouse Dach2, a homologue of Drosophila dachshund. Davis, R.J., Shen, W., Sandler, Y.I., Heanue, T.A., Mardon, G. Mech. Dev. (2001)
- Transient homologous chromosome pairing marks the onset of X inactivation. Xu, N., Tsai, C.L., Lee, J.T. Science (2006)
- Cloning and characterization of a murine brain specific gene Bpx and its human homologue lying within the Xic candidate region. Rougeulle, C., Avner, P. Hum. Mol. Genet. (1996)
- Control of Xist expression for imprinted and random X chromosome inactivation in mice. Matsui, J., Goto, Y., Takagi, N. Hum. Mol. Genet. (2001)
- Differential pattern of Xist RNA accumulation in single blastomeres isolated from 8-cell stage mouse embryos following laser zona drilling. Hartshorn, C., Rice, J.E., Wangh, L.J. Mol. Reprod. Dev. (2003)
- Developmentally-regulated changes of Xist RNA levels in single preimplantation mouse embryos, as revealed by quantitative real-time PCR. Hartshorn, C., Rice, J.E., Wangh, L.J. Mol. Reprod. Dev. (2002)
- Requirement for Xist in X chromosome inactivation. Penny, G.D., Kay, G.F., Sheardown, S.A., Rastan, S., Brockdorff, N. Nature (1996)