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Gene Review

bir-1  -  Protein BIR-1

Caenorhabditis elegans

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High impact information on bir-1

  • Deregulation of bir-1 promotes changes in ploidy, suggesting that similar deregulation of mammalian BIRPs may contribute to tumorigenesis [1].
  • The bir-1 gene is highly expressed during embryogenesis with detectable expression throughout other stages of development; bir-2 expression is detectable only in adults and embryos [2].
  • Overexpression of bir-1 was unable to inhibit developmentally occurring cell death in C. elegans and inhibition of bir-1 expression did not increase cell death [2].
  • In the C. elegans genome, bir-1 is organized in an operon together with transcription and splicing cofactor CeSKIP (skp-1) and is highly expressed during embryogenesis as well as in non-dividing cells during larval development [3].


  1. The survivin-like C. elegans BIR-1 protein acts with the Aurora-like kinase AIR-2 to affect chromosomes and the spindle midzone. Speliotes, E.K., Uren, A., Vaux, D., Horvitz, H.R. Mol. Cell (2000) [Pubmed]
  2. Caenorhabditis elegans inhibitor of apoptosis protein (IAP) homologue BIR-1 plays a conserved role in cytokinesis. Fraser, A.G., James, C., Evan, G.I., Hengartner, M.O. Curr. Biol. (1999) [Pubmed]
  3. BIR-1, the homologue of human Survivin, regulates expression of developmentally active collagen genes in C. elegans. Lib??, P., Pohludka, M., Voh??nka, J., Kostrouchov??, M., Kostrouch, D., Kostrouchov??, M., Rall, J.E., Kostrouch, Z. Folia Biol. (Praha) (2006) [Pubmed]
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