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Gene Review

skp-1  -  Protein SKP-1

Caenorhabditis elegans

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High impact information on skp-1

  • In the C. elegans genome, bir-1 is organized in an operon together with transcription and splicing cofactor CeSKIP (skp-1) and is highly expressed during embryogenesis as well as in non-dividing cells during larval development [1].

Analytical, diagnostic and therapeutic context of skp-1

  • Expression of CeSKIP (skp-1) assayed by RT-PCR and by GFP fluorescence in transgenic lines starts in embryos and continues to adulthood [2].


  1. BIR-1, the homologue of human Survivin, regulates expression of developmentally active collagen genes in C. elegans. Lib??, P., Pohludka, M., Voh??nka, J., Kostrouchov??, M., Kostrouch, D., Kostrouchov??, M., Rall, J.E., Kostrouch, Z. Folia Biol. (Praha) (2006) [Pubmed]
  2. SKIP is an indispensable factor for Caenorhabditis elegans development. Kostrouchova, M., Housa, D., Kostrouch, Z., Saudek, V., Rall, J.E. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
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