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Gene Review

SNW1  -  SNW domain containing 1

Homo sapiens

Synonyms: Bx42, NCOA-62, NCoA-62, Nuclear protein SkiP, Nuclear receptor coactivator NCoA-62, ...
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Disease relevance of SNW1


High impact information on SNW1


Biological context of SNW1

  • Coexpression of NCoA-62 in a vitamin D-responsive transient gene expression system augmented 1, 25-dihydroxyvitamin D3-activated transcription, but it had little or no effect on basal transcription or gal4-VP16-activated transcription [9].
  • This suggests that NCoA62/SKIP functions at a distal step in the transactivation process [10].
  • Using a series of reporter plasmids, we show that Skip is a potent transcriptional activator of many different promoters, the activity of which was also mapped to the conserved core SNW domain of the protein [11].
  • Furthermore, the combination of Skip and Ski can successfully overcome the G1 arrest and flat cell phenotype induced by pRb [12].
  • We further found that Prp45 activated the transcription of a reporter gene in S. cerevisiae when targeted to DNA [13].

Anatomical context of SNW1

  • Taken together, these data show that NCoA62/SKIP has properties that are consistent with those of nuclear receptor coactivators and with RNA spliceosome components, thus suggesting a potential role for NCoA62/SKIP in coupling VDR-mediated transcription to RNA splicing [1].
  • To explore potential mechanisms, NCoA62/SKIP-interacting proteins were purified from HeLa cell nuclear extracts and identified by mass spectrometry [1].
  • In the present study, we identified a nuclear localization sequence in the COOH terminus of NCoA62/SKIP and showed that NCoA62/SKIP was targeted to nuclear matrix subdomains [1].
  • SNW1/SKIP is involved in the regulation of transcription and mRNA splicing, whereas stathmin is involved in stabilization of microtubules [14].
  • Like Ski, Skip is expressed in multiple tissue types and is localized to the cell nucleus [15].

Associations of SNW1 with chemical compounds


Physical interactions of SNW1


Regulatory relationships of SNW1

  • Therefore, elevated expression of PPIL1 may play an important role in proliferation of cancer cells through the control of SNW1/SKIP and/or stathmin [14].
  • The purpose of this paper is to briefly review salient features of the coactivators involved in VDR-activated transcription and to focus on our current understanding of NCoA-62 and its interplay with other nuclear receptor coactivator proteins [22].

Other interactions of SNW1

  • Competition experiments using LXXLL peptides showed that NCoA-62/SKIP and SRC coactivators contact different domains of the VDR-RXR heterodimer [16].
  • Occult fallopian tube cancer diagnosed at prophylactic surgery in BRCA mutation carriers was exclusively distal. "Skip" areas of high-grade dysplasia were only seen in 2 patients, both of whom were BRCA mutation carriers [23].

Analytical, diagnostic and therapeutic context of SNW1

  • CONCLUSIONS: Skip metastasis are frequent in non-small-cell lung cancer and complete dissection of hilar and mediastinal lymph nodes should remain the surgical standard procedure for this disease [24].
  • CONCLUSIONS: Skip laminectomy was less invasive to the posterior extensor mechanism including the deep extensor muscles than open-door laminoplasty [25].


  1. Nuclear coactivator-62 kDa/Ski-interacting protein is a nuclear matrix-associated coactivator that may couple vitamin D receptor-mediated transcription and RNA splicing. Zhang, C., Dowd, D.R., Staal, A., Gu, C., Lian, J.B., van Wijnen, A.J., Stein, G.S., MacDonald, P.N. J. Biol. Chem. (2003) [Pubmed]
  2. The HPV-16 E7 oncoprotein binds Skip and suppresses its transcriptional activity. Prathapam, T., Kühne, C., Banks, L. Oncogene (2001) [Pubmed]
  3. Skip metastases in thyroid cancer leaping the central lymph node compartment. Machens, A., Holzhausen, H.J., Dralle, H. Archives of surgery (Chicago, Ill. : 1960) (2004) [Pubmed]
  4. Role of skip metastasis to mediastinal lymph nodes in non-small cell lung cancer. Prenzel, K.L., Mönig, S.P., Sinning, J.M., Baldus, S.E., Gutschow, C.A., Grass, G., Schneider, P.M., Hölscher, A.H. Journal of surgical oncology. (2003) [Pubmed]
  5. Re-evaluation of Axillary Skip Metastases in the Era of Sentinel Lymph Node Biopsy in Breast Cancer. Keskek, M., Balas, S., Gokoz, A., Sayek, I. Surg. Today (2006) [Pubmed]
  6. The product of an oculopharyngeal muscular dystrophy gene, poly(A)-binding protein 2, interacts with SKIP and stimulates muscle-specific gene expression. Kim, Y.J., Noguchi, S., Hayashi, Y.K., Tsukahara, T., Shimizu, T., Arahata, K. Hum. Mol. Genet. (2001) [Pubmed]
  7. SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC function. Zhou, S., Fujimuro, M., Hsieh, J.J., Chen, L., Miyamoto, A., Weinmaster, G., Hayward, S.D. Mol. Cell. Biol. (2000) [Pubmed]
  8. Medaka simplet (FAM53B) belongs to a family of novel vertebrate genes controlling cell proliferation. Thermes, V., Candal, E., Alunni, A., Serin, G., Bourrat, F., Joly, J.S. Development (2006) [Pubmed]
  9. Isolation and characterization of a novel coactivator protein, NCoA-62, involved in vitamin D-mediated transcription. Baudino, T.A., Kraichely, D.M., Jefcoat, S.C., Winchester, S.K., Partridge, N.C., MacDonald, P.N. J. Biol. Chem. (1998) [Pubmed]
  10. Emerging insights into the coactivator role of NCoA62/SKIP in Vitamin D-mediated transcription. MacDonald, P.N., Dowd, D.R., Zhang, C., Gu, C. J. Steroid Biochem. Mol. Biol. (2004) [Pubmed]
  11. Ski interacts with the evolutionarily conserved SNW domain of Skip. Prathapam, T., Kühne, C., Hayman, M., Banks, L. Nucleic Acids Res. (2001) [Pubmed]
  12. Skip interacts with the retinoblastoma tumor suppressor and inhibits its transcriptional repression activity. Prathapam, T., Kühne, C., Banks, L. Nucleic Acids Res. (2002) [Pubmed]
  13. Functional mapping of Saccharomyces cerevisiae Prp45 identifies the SNW domain as essential for viability. Martinkova, K., Lebduska, P., Skruzny, M., Folk, P., Puta, F. J. Biochem. (2002) [Pubmed]
  14. Overexpression of peptidyl-prolyl isomerase-like 1 is associated with the growth of colon cancer cells. Obama, K., Kato, T., Hasegawa, S., Satoh, S., Nakamura, Y., Furukawa, Y. Clin. Cancer Res. (2006) [Pubmed]
  15. The Ski oncoprotein interacts with Skip, the human homolog of Drosophila Bx42. Dahl, R., Wani, B., Hayman, M.J. Oncogene (1998) [Pubmed]
  16. Ternary complexes and cooperative interplay between NCoA-62/Ski-interacting protein and steroid receptor coactivators in vitamin D receptor-mediated transcription. Zhang, C., Baudino, T.A., Dowd, D.R., Tokumaru, H., Wang, W., MacDonald, P.N. J. Biol. Chem. (2001) [Pubmed]
  17. The homolog of chromatin binding protein Bx42 identified in Dictyostelium. Folk, P., Půta, F., Krpejsová, L., Blahůsková, A., Markos, A., Rabino, M., Dottin, R.P. Gene (1996) [Pubmed]
  18. CHES1/FOXN3 interacts with Ski-interacting protein and acts as a transcriptional repressor. Scott, K.L., Plon, S.E. Gene (2005) [Pubmed]
  19. Ski-interacting protein interacts with Smad proteins to augment transforming growth factor-beta-dependent transcription. Leong, G.M., Subramaniam, N., Figueroa, J., Flanagan, J.L., Hayman, M.J., Eisman, J.A., Kouzmenko, A.P. J. Biol. Chem. (2001) [Pubmed]
  20. Characterization of human LNX, a novel ligand of Numb protein X that is downregulated in human gliomas. Chen, J., Xu, J., Zhao, W., Hu, G., Cheng, H., Kang, Y., Xie, Y., Lu, Y. Int. J. Biochem. Cell Biol. (2005) [Pubmed]
  21. Characterization of the biological functions of a transcription factor, c-myc intron binding protein 1 (MIBP1). Fukuda, S., Yamasaki, Y., Iwaki, T., Kawasaki, H., Akieda, S., Fukuchi, N., Tahira, T., Hayashi, K. J. Biochem. (2002) [Pubmed]
  22. Vitamin D receptor and nuclear receptor coactivators: crucial interactions in vitamin D-mediated transcription. MacDonald, P.N., Baudino, T.A., Tokumaru, H., Dowd, D.R., Zhang, C. Steroids (2001) [Pubmed]
  23. BRCA-mutation-associated fallopian tube carcinoma: a distinct clinical phenotype? Cass, I., Holschneider, C., Datta, N., Barbuto, D., Walts, A.E., Karlan, B.Y. Obstetrics and gynecology. (2005) [Pubmed]
  24. Analysis of risk factors for skip lymphatic metastasis and their prognostic value in operated N2 non-small-cell lung carcinoma. Benoit, L., Anusca, A., Ortega-Deballon, P., Cheynel, N., Bernard, A., Favre, J.P. European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology. (2006) [Pubmed]
  25. Results of skip laminectomy-minimum 2-year follow-up study compared with open-door laminoplasty. Shiraishi, T., Fukuda, K., Yato, Y., Nakamura, M., Ikegami, T. Spine. (2003) [Pubmed]
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