Gene Review:
ceh-32 - Protein CEH-32
Caenorhabditis elegans
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High impact information on ceh-32
- The Caenorhabditis elegans Six/sine oculis class homeobox gene ceh-32 is required for head morphogenesis [1].
- Our results suggest that VAB-3 acts upstream of ceh-32 during head morphogenesis and directly induces ceh-32 [1].
- In addition, we demonstrate that VAB-3 is able to bind directly to the ceh-32 upstream regulatory region in vitro and to activate reporter gene transcription in a yeast one-hybrid system [1].
- Proteins encoded by this gene family are transcription factors sharing two conserved domains, the homeodomain and the Six/sine oculis domain, both involved in DNA binding. ceh-32 expression was detected during embryogenesis in hypodermal and neuronal precursor cells and later in descendants of these cells as well as in gonadal sheath cells [1].
References
- The Caenorhabditis elegans Six/sine oculis class homeobox gene ceh-32 is required for head morphogenesis. Dozier, C., Kagoshima, H., Niklaus, G., Cassata, G., Bürglin, T.R. Dev. Biol. (2001) [Pubmed]
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