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Gene Review

Nat3  -  N-acetyltransferase 3

Mus musculus

Synonyms: Aac3, Arylamide acetylase 3, Arylamine N-acetyltransferase 3, N-acetyltransferase type 3, NAT-3
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High impact information on Nat3

  • In the present study, Nat1*, Nat2*8, and Nat3* were expressed in COS-1 cells, and their substrate selectivity was evaluated with various substrates [1].
  • For the substrates tested in this study, mouse Nat3 exhibited activity only toward 5-aminosalicylic acid and only at 1/20 the activity shown by Nat2 [1].
  • Recombinant NAT1, NAT2, and NAT3 proteins catalyzed N-, O-, and N,O-acetyltransferase activities [2].
  • NAT3 catalyzed aromatic amine N-acetyltransferase activities at very low rates, which confirms a previous study [2].
  • We show that Nat3 is close to Nat1 and Nat2, by screening of a P1 artificial chromosome (PAC) library and provide cytogenetic evidence for co-localisation of the three genes in chromosome region 8 B3.1-B3 [3].

Biological context of Nat3


Other interactions of Nat3

  • There are three functional genes in mice (Nat1, Nat2, and Nat3) encoding for three NAT isoenzymes [3].

Analytical, diagnostic and therapeutic context of Nat3

  • Activity of the NAT3 allozymes was hardly detectable, although the Nat3 gene does appear to be transcribed, since mRNA was detected by RT-PCR in the spleen [4].


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