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Gene Review

Nfix  -  nuclear factor I/X

Mus musculus

Synonyms: CCAAT-box-binding transcription factor, CTF, NF-I/X, NF1-X, NFI-X, ...
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Disease relevance of Nfix


High impact information on Nfix

  • The relative activation potentials for the NFI isoforms differed between the two promoters, with NFI-X being the strongest activator of NFI-Ad and NFI-B being the strongest activator of the MMTV promoter [2].
  • Stable transfection of activated Ha-ras into a number of murine cells correlated with a down-regulation of the expression of the NF1 genes NF1/CTF and NF1/X [3].
  • In the present study, we have focused on a region designated MB3, which is located between -93 to -130 nucleotides with respect to the RNA start site, and contains a binding site for the NF1/CTF family of transcription activators [4].
  • Methylation interference experiments have allowed the identification of the G-residues within nucleotides -100 to -108, named MB3a, which are distinct from the NF1/CTF of MB3 that contact with nuclear proteins to form the major C1 complex [4].
  • Mapping of the murine nuclear factor I/X gene (Nfix) to mouse chromosome 8 C1-2 by FISH [5].

Anatomical context of Nfix

  • In the kidney of normotensive vs hypertensive rats, the nuclear protein factors NF1/CTF and SP1 bind differently to the renal kallikrein promoter, but similarly in the salivary gland [6].


  1. Nuclear factor I X deficiency causes brain malformation and severe skeletal defects. Driller, K., Pagenstecher, A., Uhl, M., Omran, H., Berlis, A., Gründer, A., Sippel, A.E. Mol. Cell. Biol. (2007) [Pubmed]
  2. Nuclear factor I (NFI) isoforms differentially activate simple versus complex NFI-responsive promoters. Chaudhry, A.Z., Vitullo, A.D., Gronostajski, R.M. J. Biol. Chem. (1998) [Pubmed]
  3. Post-transcriptional down-regulation of expression of transcription factor NF1 by Ha-ras oncogene. Nebl, G., Mermod, N., Cato, A.C. J. Biol. Chem. (1994) [Pubmed]
  4. Regulation of myelin basic protein gene transcription: identification of a distal cis-acting regulatory element. Haque, N.S., Haas, S., Knobler, R.L., Khalili, K. J. Cell. Physiol. (1995) [Pubmed]
  5. Mapping of the murine nuclear factor I/X gene (Nfix) to mouse chromosome 8 C1-2 by FISH. Scherthan, H., Seisenberger, C., Greulich, K., Winnacker, E.L. Genomics (1994) [Pubmed]
  6. Regulatory elements in the promoter region of the renal kallikrein gene in normotensive vs hypertensive rats. Wang, C., Chen, Y.P., Chao, L., Chao, J. Biochem. Biophys. Res. Commun. (1995) [Pubmed]
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