The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Editor

Share

Personal info

View

Links

  • Homologues
  • NCBI Gene
  • NCBI SNP
  • iHOP resource
  • SNPedia
  • UniProt
  • Ensembl

Table of contents

About

Terms

 

Gene Review: 

Nfix  -  nuclear factor I/X

Mus musculus

Synonyms: CCAAT-box-binding transcription factor, CTF, NF-I/X, NF1-X, NFI-X, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of Nfix

 

High impact information on Nfix

  • The relative activation potentials for the NFI isoforms differed between the two promoters, with NFI-X being the strongest activator of NFI-Ad and NFI-B being the strongest activator of the MMTV promoter [2].
  • Stable transfection of activated Ha-ras into a number of murine cells correlated with a down-regulation of the expression of the NF1 genes NF1/CTF and NF1/X [3].
  • In the present study, we have focused on a region designated MB3, which is located between -93 to -130 nucleotides with respect to the RNA start site, and contains a binding site for the NF1/CTF family of transcription activators [4].
  • Methylation interference experiments have allowed the identification of the G-residues within nucleotides -100 to -108, named MB3a, which are distinct from the NF1/CTF of MB3 that contact with nuclear proteins to form the major C1 complex [4].
  • Mapping of the murine nuclear factor I/X gene (Nfix) to mouse chromosome 8 C1-2 by FISH [5].
 

Anatomical context of Nfix

  • In the kidney of normotensive vs hypertensive rats, the nuclear protein factors NF1/CTF and SP1 bind differently to the renal kallikrein promoter, but similarly in the salivary gland [6].

References

  1. Nuclear factor I X deficiency causes brain malformation and severe skeletal defects. Driller, K., Pagenstecher, A., Uhl, M., Omran, H., Berlis, A., Gründer, A., Sippel, A.E. Mol. Cell. Biol. (2007) [Pubmed]
  2. Nuclear factor I (NFI) isoforms differentially activate simple versus complex NFI-responsive promoters. Chaudhry, A.Z., Vitullo, A.D., Gronostajski, R.M. J. Biol. Chem. (1998) [Pubmed]
  3. Post-transcriptional down-regulation of expression of transcription factor NF1 by Ha-ras oncogene. Nebl, G., Mermod, N., Cato, A.C. J. Biol. Chem. (1994) [Pubmed]
  4. Regulation of myelin basic protein gene transcription: identification of a distal cis-acting regulatory element. Haque, N.S., Haas, S., Knobler, R.L., Khalili, K. J. Cell. Physiol. (1995) [Pubmed]
  5. Mapping of the murine nuclear factor I/X gene (Nfix) to mouse chromosome 8 C1-2 by FISH. Scherthan, H., Seisenberger, C., Greulich, K., Winnacker, E.L. Genomics (1994) [Pubmed]
  6. Regulatory elements in the promoter region of the renal kallikrein gene in normotensive vs hypertensive rats. Wang, C., Chen, Y.P., Chao, L., Chao, J. Biochem. Biophys. Res. Commun. (1995) [Pubmed]
Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenesOpen Access LicencePrivacy PolicyTerms of Useapsburg
 
WikiGenes - Universities