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Gene Review:

lim-4 - Protein LIM-4

Caenorhabditis elegans

Hobert, O. et al., Wenick, A.S. et al., Lichtsteiner, S. et al., Röckelein, I. et al., Toms, N. et al., et al.

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High impact information on LIM-homeodomain

A LIM-homeodomain combinatorial code for motor-neuron pathway selection [1].
Thus, the TTX-3 LIM homeodomain protein is likely to regulate the expression of target genes required late in AIY differentiation for the function of this interneuron in the thermoregulatory pathway [2].
Whereas the POU homeodomain protein, UNC-86, alone was able to activate transcription of the mec-3 promoter in vitro, the LIM homeodomain protein, MEC-3, failed to bind DNA or activate transcription on its own [3].
The POU homeodomain protein UNC-86 and the LIM homeodomain protein MEC-3 are essential for the differentiation of the six mechanoreceptor neurons in the nematode Caenorhabditis elegans [4].
Here, we report that the LIM-homeodomain factor LIM-4 regulates ADF serotonergic phenotype [5].

Biological context of LIM-homeodomain

Using genome-wide phylogenetic footprinting, we delineated the location, distribution, and evolution of AIY-specific cis-regulatory elements throughout the genome and thereby defined a large battery of AIY-expressed genes, all of which represent direct Paired/LIM homeodomain target genes [6].

Other interactions of LIM-homeodomain

BACKGROUND: The Caenorhabditis elegans gene mec-3 encodes a LIM-homeodomain protein that is a master regulator of touch receptor neuron genes [7].

References

A LIM-homeodomain combinatorial code for motor-neuron pathway selection. Thor, S., Andersson, S.G., Tomlinson, A., Thomas, J.B. Nature (1999) [Pubmed]
Regulation of interneuron function in the C. elegans thermoregulatory pathway by the ttx-3 LIM homeobox gene. Hobert, O., Mori, I., Yamashita, Y., Honda, H., Ohshima, Y., Liu, Y., Ruvkun, G. Neuron (1997) [Pubmed]
Synergistic activation of transcription by UNC-86 and MEC-3 in Caenorhabditis elegans embryo extracts. Lichtsteiner, S., Tjian, R. EMBO J. (1995) [Pubmed]
Identification of amino acid residues in the Caenorhabditis elegans POU protein UNC-86 that mediate UNC-86-MEC-3-DNA ternary complex formation. Röckelein, I., Röhrig, S., Donhauser, R., Eimer, S., Baumeister, R. Mol. Cell. Biol. (2000) [Pubmed]
Cell-type specific regulation of serotonergic identity by the C. elegans LIM-homeodomain factor LIM-4. Zheng, X., Chung, S., Tanabe, T., Sze, J.Y. Dev. Biol. (2005) [Pubmed]
Genomic cis-regulatory architecture and trans-acting regulators of a single interneuron-specific gene battery in C. elegans. Wenick, A.S., Hobert, O. Dev. Cell (2004) [Pubmed]
High copy arrays containing a sequence upstream of mec-3 alter cell migration and axonal morphology in C. elegans. Toms, N., Cooper, J., Patchen, B., Aamodt, E. BMC Dev. Biol. (2001) [Pubmed]

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