Gene Review:
BMEII0681 - virulence protein
Brucella melitensis bv. 1 str. 16M
Porte,
Naroeni,
Ouahrani-Bettache,
Liautard,
Roop,
Gee,
Robertson,
Richardson,
Ng,
Winkler,
Paulsen,
Seshadri,
Nelson,
Eisen,
Heidelberg,
Read,
Dodson,
Umayam,
Brinkac,
Beanan,
Daugherty,
Deboy,
Durkin,
Kolonay,
Madupu,
Nelson,
Ayodeji,
Kraul,
Shetty,
Malek,
Van Aken,
Riedmuller,
Tettelin,
Gill,
White,
Salzberg,
Hoover,
Lindler,
Halling,
Boyle,
Fraser,
Jones,
Bolken,
Jones,
Zeller,
Hruby,
Guilloteau,
Laroucau,
Olivier,
Grillo,
Marin,
Verger,
Blasco,
Danese,
Haine,
Delrue,
Tibor,
Lestrate,
Stevaux,
Mertens,
Paquet,
Godfroid,
De Bolle,
Letesson,
Gross,
Bouaboula,
Casellas,
Liautard,
Dornand,
Pettigrew,
Fennie,
Rittig,
Alvarez-Martinez,
Porte,
Liautard,
Rouot,
Parent,
Bellaire,
Murphy,
Roop,
Elzer,
Baldwin,
- The Brucella suis genome reveals fundamental similarities between animal and plant pathogens and symbionts. Paulsen, I.T., Seshadri, R., Nelson, K.E., Eisen, J.A., Heidelberg, J.F., Read, T.D., Dodson, R.J., Umayam, L., Brinkac, L.M., Beanan, M.J., Daugherty, S.C., Deboy, R.T., Durkin, A.S., Kolonay, J.F., Madupu, R., Nelson, W.C., Ayodeji, B., Kraul, M., Shetty, J., Malek, J., Van Aken, S.E., Riedmuller, S., Tettelin, H., Gill, S.R., White, O., Salzberg, S.L., Hoover, D.L., Lindler, L.E., Halling, S.M., Boyle, S.M., Fraser, C.M. Proc. Natl. Acad. Sci. U.S.A. (2002)
- Cyclic beta-1,2-glucan is a Brucella virulence factor required for intracellular survival. Arellano-Reynoso, B., Lapaque, N., Salcedo, S., Briones, G., Ciocchini, A.E., Ugalde, R., Moreno, E., Moriyón, I., Gorvel, J.P. Nat. Immunol. (2005)
- Conserved DegP protease in gram-positive bacteria is essential for thermal and oxidative tolerance and full virulence in Streptococcus pyogenes. Jones, C.H., Bolken, T.C., Jones, K.F., Zeller, G.O., Hruby, D.E. Infect. Immun. (2001)
- Virulence criteria for Brucella abortus strains as determined by interferon regulatory factor 1-deficient mice. Ko, J., Gendron-Fitzpatrick, A., Ficht, T.A., Splitter, G.A. Infect. Immun. (2002)
- Genomic subtraction followed by dot blot screening of Streptococcus pneumoniae clinical and carriage isolates identifies genetic differences associated with strains that cause otitis media. Pettigrew, M.M., Fennie, K.P. Infect. Immun. (2005)
- Brucella evades macrophage killing via VirB-dependent sustained interactions with the endoplasmic reticulum. Celli, J., de Chastellier, C., Franchini, D.M., Pizarro-Cerda, J., Moreno, E., Gorvel, J.P. J. Exp. Med. (2003)
- Brucella stationary-phase gene expression and virulence. Roop, R.M., Gee, J.M., Robertson, G.T., Richardson, J.M., Ng, W.L., Winkler, M.E. Annu. Rev. Microbiol. (2003)
- Dimerization and interactions of Brucella suis VirB8 with VirB4 and VirB10 are required for its biological activity. Paschos, A., Patey, G., Sivanesan, D., Gao, C., Bayliss, R., Waksman, G., O'callaghan, D., Baron, C. Proc. Natl. Acad. Sci. U.S.A. (2006)
- Subversion and utilization of the host cell cyclic adenosine 5'-monophosphate/protein kinase A pathway by Brucella during macrophage infection. Gross, A., Bouaboula, M., Casellas, P., Liautard, J.P., Dornand, J. J. Immunol. (2003)
- Role of the Brucella suis lipopolysaccharide O antigen in phagosomal genesis and in inhibition of phagosome-lysosome fusion in murine macrophages. Porte, F., Naroeni, A., Ouahrani-Bettache, S., Liautard, J.P. Infect. Immun. (2003)
- The siderophore 2,3-dihydroxybenzoic acid is not required for virulence of Brucella abortus in BALB/c mice. Bellaire, B.H., Elzer, P.H., Baldwin, C.L., Roop, R.M. Infect. Immun. (1999)
- Synthesis of phosphatidylcholine, a typical eukaryotic phospholipid, is necessary for full virulence of the intracellular bacterial parasite Brucella abortus. Conde-Alvarez, R., Grilló, M.J., Salcedo, S.P., de Miguel, M.J., Fugier, E., Gorvel, J.P., Moriyón, I., Iriarte, M. Cell. Microbiol. (2006)
- The Ton system, an ABC transporter, and a universally conserved GTPase are involved in iron utilization by Brucella melitensis 16M. Danese, I., Haine, V., Delrue, R.M., Tibor, A., Lestrate, P., Stevaux, O., Mertens, P., Paquet, J.Y., Godfroid, J., De Bolle, X., Letesson, J.J. Infect. Immun. (2004)
- Intact purine biosynthesis pathways are required for wild-type virulence of Brucella abortus 2308 in the BALB/c mouse model. Alcantara, R.B., Read, R.D., Valderas, M.W., Brown, T.D., Roop, R.M. Infect. Immun. (2004)
- Integration host factor is involved in transcriptional regulation of the Brucella abortus virB operon. Sieira, R., Comerci, D.J., Pietrasanta, L.I., Ugalde, R.A. Mol. Microbiol. (2004)
- Transposon-derived Brucella abortus rough mutants are attenuated and exhibit reduced intracellular survival. Allen, C.A., Adams, L.G., Ficht, T.A. Infect. Immun. (1998)
- Molecular characterization of a Brucella species large DNA fragment deleted in Brucella abortus strains: evidence for a locus involved in the synthesis of a polysaccharide. Vizcaíno, N., Cloeckaert, A., Zygmunt, M.S., Fernández-Lago, L. Infect. Immun. (1999)
- Isolation and characterization of mini-Tn5Km2 insertion mutants of Brucella abortus deficient in internalization and intracellular growth in HeLa cells. Kim, S., Watarai, M., Kondo, Y., Erdenebaatar, J., Makino, S., Shirahata, T. Infect. Immun. (2003)
- Whole-genome analyses of speciation events in pathogenic Brucellae. Chain, P.S., Comerci, D.J., Tolmasky, M.E., Larimer, F.W., Malfatti, S.A., Vergez, L.M., Aguero, F., Land, M.L., Ugalde, R.A., Garcia, E. Infect. Immun. (2005)
- Brucella abortus cyclic beta-1,2-glucan mutants have reduced virulence in mice and are defective in intracellular replication in HeLa cells. Briones, G., Iñón de Iannino, N., Roset, M., Vigliocco, A., Paulo, P.S., Ugalde, R.A. Infect. Immun. (2001)
- Production of the type IV secretion system differs among Brucella species as revealed with VirB5- and VirB8-specific antisera. Rouot, B., Alvarez-Martinez, M.T., Marius, C., Menanteau, P., Guilloteau, L., Boigegrain, R.A., Zumbihl, R., O'Callaghan, D., Domke, N., Baron, C. Infect. Immun. (2003)
- Characterization and genetic complementation of a Brucella abortus high-temperature-requirement A (htrA) deletion mutant. Elzer, P.H., Phillips, R.W., Kovach, M.E., Peterson, K.M., Roop, R.M. Infect. Immun. (1994)
- Intracellular survival of Brucella spp. in human monocytes involves conventional uptake but special phagosomes. Rittig, M.G., Alvarez-Martinez, M.T., Porte, F., Liautard, J.P., Rouot, B. Infect. Immun. (2001)
- Smooth phage-resistant Brucella abortus from bovine tissue. Harrington, R., Bond, D.R., Brown, G.M. J. Clin. Microbiol. (1977)
- Analysis of the behavior of eryC mutants of Brucella suis attenuated in macrophages. Burkhardt, S., Jiménez de Bagüés, M.P., Liautard, J.P., Köhler, S. Infect. Immun. (2005)
- Role in virulence of a Brucella abortus protein exhibiting lectin-like activity. Vemulapalli, T.H., Vemulapalli, R., Schurig, G.G., Boyle, S.M., Sriranganathan, N. Infect. Immun. (2006)
- Surface macromolecules and virulence in intracellular parasitism: comparison of cell envelope components of smooth and rough strains of Brucella abortus. Kreutzer, D.L., Robertson, D.C. Infect. Immun. (1979)
- Membrane topology analysis of cyclic glucan synthase, a virulence determinant of Brucella abortus. Ciocchini, A.E., Roset, M.S., Iñón de Iannino, N., Ugalde, R.A. J. Bacteriol. (2004)
- Brucella abortus siderophore 2,3-dihydroxybenzoic acid (DHBA) facilitates intracellular survival of the bacteria. Parent, M.A., Bellaire, B.H., Murphy, E.A., Roop, R.M., Elzer, P.H., Baldwin, C.L. Microb. Pathog. (2002)
- The identification of two protective DNA vaccines from a panel of five plasmid constructs encoding Brucella melitensis 16M genes. Commander, N.J., Spencer, S.A., Wren, B.W., Macmillan, A.P. Vaccine (2007)
- Attenuated bioluminescent Brucella melitensis mutants GR019 (virB4), GR024 (galE), and GR026 (BMEI1090-BMEI1091) confer protection in mice. Rajashekara, G., Glover, D.A., Banai, M., O'Callaghan, D., Splitter, G.A. Infect. Immun. (2006)
- Role of catalase in the virulence of Brucella melitensis in pregnant goats. Gee, J.M., Kovach, M.E., Grippe, V.K., Hagius, S., Walker, J.V., Elzer, P.H., Roop, R.M. Vet. Microbiol. (2004)
- Comparative proteome analysis of Brucella melitensis vaccine strain Rev 1 and a virulent strain, 16M. Eschenbrenner, M., Wagner, M.A., Horn, T.A., Kraycer, J.A., Mujer, C.V., Hagius, S., Elzer, P., DelVecchio, V.G. J. Bacteriol. (2002)
- Residual virulence and immunogenicity of CGV26 and CGV2631 B. melitensis Rev. 1 deletion mutant strains in sheep after subcutaneous or conjunctival vaccination. Guilloteau, L.A., Laroucau, K., Olivier, M., Grillo, M.J., Marin, C.M., Verger, J.M., Blasco, J.M. Vaccine (2006)
- Brucella abortus INTA2, a novel strain 19 (Delta)bp26::luc (Delta)bmp18 double mutant lacking drug resistance markers. Campos, E., Cravero, S.L., Delgui, L., Mora, I., Kahn, N., Arese, A.I., Rossetti, O.L. Vet. Microbiol. (2002)
- Virulence of Brucella: bacterial growth and decline in mice. Plommet, M., Plommet, A.M. Ann. Rech. Vet. (1988)