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Gene Review:

F25H2.7 - Protein F25H2.7

Caenorhabditis elegans

Nishihara, S. et al., Kozma, K. et al., Simmons, A.D. et al., Izumikawa, T. et al., Leipelt, M. et al., et al.

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High impact information on glycosyltransferase

One recent study has also reported that these proteins co-purify with glycosyltransferase (GlcA and GlcNAc transferase) activity and on that basis it has been postulated that they are themselves glycosyl-transferases [1].
Here we identify the putative glycosyltransferase, B3GTL, as the beta1,3-glucosyltransferase involved in the biosynthesis of this disaccharide [2].
4. Despite little glycosyltransferase activity of the gene product, chondroitin polymerization was demonstrated as in the case of mammals when PAR2.4 was coexpressed with cChSy in vitro [3].
The glycosyltransferase gene expressions led to the biosynthesis of different molecular species of glucosylceramides that contained either C18 or very long chain fatty acids [4].
Phylogenetic analysis confirmed their membership of the GT-20 glycosyltransferase family, but indicated an accelerated rate of molecular evolution [5].

Associations of glycosyltransferase with chemical compounds

For analyses of the basic physiological functions of glycans, we established the Drosophila inducible RNAi knockdown system and applied it to one glycosyltransferase and one transporter, proteoglycan UDP-galactose: beta-xylose beta1,4galactosyltransferase I and the PAPS-transporter, respectively [6].

References

A direct interaction between EXT proteins and glycosyltransferases is defective in hereditary multiple exostoses. Simmons, A.D., Musy, M.M., Lopes, C.S., Hwang, L.Y., Yang, Y.P., Lovett, M. Hum. Mol. Genet. (1999) [Pubmed]
Identification and Characterization of abeta1,3-Glucosyltransferase That Synthesizes the Glc-beta1,3-Fuc Disaccharide on Thrombospondin Type 1 Repeats. Kozma, K., Keusch, J.J., Hegemann, B., Luther, K.B., Klein, D., Hess, D., Haltiwanger, R.S., Hofsteenge, J. J. Biol. Chem. (2006) [Pubmed]
Nematode chondroitin polymerizing factor showing cell-/organ-specific expression is indispensable for chondroitin synthesis and embryonic cell division. Izumikawa, T., Kitagawa, H., Mizuguchi, S., Nomura, K.H., Nomura, K., Tamura, J., Gengyo-Ando, K., Mitani, S., Sugahara, K. J. Biol. Chem. (2004) [Pubmed]
Glucosylceramide synthases, a gene family responsible for the biosynthesis of glucosphingolipids in animals, plants, and fungi. Leipelt, M., Warnecke, D., Zähringer, U., Ott, C., Müller, F., Hube, B., Heinz, E. J. Biol. Chem. (2001) [Pubmed]
Dehydration-induced tps gene transcripts from an anhydrobiotic nematode contain novel spliced leaders and encode atypical GT-20 family proteins. Goyal, K., Browne, J.A., Burnell, A.M., Tunnacliffe, A. Biochimie (2005) [Pubmed]
Approach for functional analysis of glycan using RNA interference. Nishihara, S., Ueda, R., Goto, S., Toyoda, H., Ishida, H., Nakamura, M. Glycoconj. J. (2004) [Pubmed]

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