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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

KAT2B  -  K(lysine) acetyltransferase 2B

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High impact information on PCAF

  • We suggest that linker histones hinder access of PCAF, and perhaps other HATs, to their target acetylation sites and that perturbation of the linker histone organization in chromatin is a prerequisite for efficient acetylation of the histone tails in nucleosomes [1].
  • Significantly, five of six other TAF(II)s tested were also rapidly depleted, but levels of the TATA binding protein and subunits of PCAF/SAGA were at most modestly compromised [2].
  • We have employed gene targeting coupled with conditional expression to construct a chicken DT40 cell line in which a tetracycline (Tet)-repressible promoter is exclusively responsible for expression of cTAF(II)31, a histone-like TAF(II) residing in both the transcription factor TFIID and the histone acetylase complex PCAF/SAGA [2].

References

  1. Histone H1 is a specific repressor of core histone acetylation in chromatin. Herrera, J.E., West, K.L., Schiltz, R.L., Nakatani, Y., Bustin, M. Mol. Cell. Biol. (2000) [Pubmed]
  2. Robust mRNA transcription in chicken DT40 cells depleted of TAF(II)31 suggests both functional degeneracy and evolutionary divergence. Chen, Z., Manley, J.L. Mol. Cell. Biol. (2000) [Pubmed]
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