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Gene Review

Pdcd6ip  -  programmed cell death 6 interacting protein

Mus musculus

Synonyms: AI480591, AIP1, ALG-2-interacting protein 1, ALG-2-interacting protein X, AW544830, ...
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Disease relevance of Pdcd6ip

  • Our study suggests that Alix/AIP1 protein expression and ERK1/2 activation are decreased in severe colitis [1].

High impact information on Pdcd6ip


Biological context of Pdcd6ip

  • Therefore, Alix represents a molecular link between the endolysosomal system and the cell death machinery [4].

Anatomical context of Pdcd6ip


  1. Enterococcus faecalis strains differentially regulate Alix/AIP1 protein expression and ERK 1/2 activation in intestinal epithelial cells in the context of chronic experimental colitis. Hoffmann, M., Kim, S.C., Sartor, R.B., Haller, D. J. Proteome Res. (2009) [Pubmed]
  2. Alix, a protein regulating endosomal trafficking, is involved in neuronal death. Trioulier, Y., Torch, S., Blot, B., Cristina, N., Chatellard-Causse, C., Verna, J.M., Sadoul, R. J. Biol. Chem. (2004) [Pubmed]
  3. Alix (ALG-2-interacting protein X), a protein involved in apoptosis, binds to endophilins and induces cytoplasmic vacuolization. Chatellard-Causse, C., Blot, B., Cristina, N., Torch, S., Missotten, M., Sadoul, R. J. Biol. Chem. (2002) [Pubmed]
  4. Alix, making a link between apoptosis-linked gene-2, the endosomal sorting complexes required for transport, and neuronal death in vivo. Mahul-Mellier, A.L., Hemming, F.J., Blot, B., Fraboulet, S., Sadoul, R. J. Neurosci. (2006) [Pubmed]
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