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Pde6g  -  phosphodiesterase 6G, cGMP-specific, rod,...

Mus musculus

Synonyms: GMP-PDE gamma, Pdeg, Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma, p3AT
 
 
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Disease relevance of Pde6g

  • In the past few years, we have been studying an allelic series of mutations in the gamma-subunit of the cGMP phosphodiesterase gene (Pdeg) that resulted in visual defects ranging from stationary night blindness to progressive retinal degeneration [1].
 

High impact information on Pde6g

  • Pdeg(tm1)/Pdeg(tm1) mice (which lack PDEgamma owing to a targeted disruption of the Pdeg gene) suffer from a very rapid and severe photoreceptor degeneration [2].
  • Pdeg(tm1)/Pdeg(tm1) mice that lack PDEgamma due to a targeted disruption of the gene encoding PDEgamma, (Pdeg) suffer from a very rapid and severe photoreceptor degeneration [3].
  • Our results suggest that the structural gene for the gamma-subunit of cGMP-PDE from mouse retina, which we have designated 'Pdeg', is not the primary defect in rd disease, as the locus of this genetic defect is on mouse chromosome 5 [4].
 

Biological context of Pde6g

  • Here we describe the morphology and physiology of the retina in mice carrying four different Pdeg alleles: Pdeg(tm), Del 7C, Y84G, and W70A and the effect that these mutations of PDE gamma have on components of the activation and deactivation phases of phototransduction [1].
 

Anatomical context of Pde6g

  • Second, the expression of p14 immunostained with antibodies recognizing both rod and cone PDEgamma was substantially reduced in lung membranes from Pde6g-/- mice [5].
  • Here, we report that mouse lung expresses gamma-subunit (PDEgamma) transcripts of the rod and cone photoreceptor cGMP phosphodiesterase genes (Pde6g and Pde6h, respectively) [5].

References

  1. Stationary night blindness or progressive retinal degeneration in mice carrying different alleles of PDE gamma. Farber, D.B., Tsang, S.H. Front. Biosci. (2003) [Pubmed]
  2. In vivo studies of the gamma subunit of retinal cGMP-phophodiesterase with a substitution of tyrosine-84. Tsang, S.H., Yamashita, C.K., Doi, K., Salchow, D.J., Bouvier, N., Mendelsohn, M., Gouras, P., Farber, D.B., Goff, S.P. Biochem. J. (2001) [Pubmed]
  3. The positive role of the carboxyl terminus of the gamma subunit of retinal cGMP-phosphodiesterase in maintaining phosphodiesterase activity in vivo. Tsang, S.H., Yamashita, C.K., Lee, W.H., Lin, C.S., Goff, S.P., Gouras, P., Farber, D.B. Vision Res. (2002) [Pubmed]
  4. The gene for the gamma-subunit of retinal cGMP-phosphodiesterase is on mouse chromosome 11. Danciger, M., Tuteja, N., Kozak, C.A., Farber, D.B. Exp. Eye Res. (1989) [Pubmed]
  5. The identification of the inhibitory gamma-subunits of the type 6 retinal cyclic guanosine monophosphate phosphodiesterase in non-retinal tissues: differential processing of mRNA transcripts. Tate, R.J., Arshavsky, V.Y., Pyne, N.J. Genomics (2002) [Pubmed]
 
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