Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

DYX1 - dyslexia susceptibility 1

Homo sapiens

Synonyms: RD

Wang, Y. et al., Fagerheim, T. et al., Fisher, S.E. et al., Petryshen, T.L. et al., Tzenova, J. et al., et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Psychiatry related information on DYX1

Possible localisations of genes for dyslexia have been reported on chromosomes 15 (DYX1), 6p21.3-23 (DYX2), and 1p over the last 15 years [1].

High impact information on DYX1

All attempts to map quantitative-trait loci (QTLs) influencing dyslexia susceptibility have targeted specific chromosomal regions, so that inferences regarding genetic etiology have been made on the basis of very limited information [2].
The isolation and molecular characterisation of this newly reported gene on chromosome 2 (DYX3) and DYX1 will thus provide new and exciting insights into the processes involved in reading and spelling [1].
In this study we report that in utero RNA interference against the rat homolog of another candidate dyslexia susceptibility gene, DYX1C1, disrupts neuronal migration in developing neocortex [3].
Rodent homologues of two candidate dyslexia susceptibility genes, Kiaa0319 and Dcdc2, have been shown to play roles in neuronal migration in developing cerebral neocortex [3].
A linkage study of 96 dyslexia families containing at least two affected siblings (totaling 877 individuals) has found evidence for a dyslexia susceptibility gene on chromosome 6q11.2-q12 (assigned the name DYX4) [4].

Anatomical context of DYX1

In conclusion, DYX1C1, similar to two other candidate dyslexia susceptibility genes, functions in neuronal migration in rat neocortex [3].

Other interactions of DYX1

Putative functional alleles of DYX1C1 are not associated with dyslexia susceptibility in a large sample of sibling pairs from the UK [5].
In conclusion, our study confirms and strengthens recent findings of a dyslexia susceptibility gene on chromosome 1p34-p36 (now designated DYX8) [6].

References

A new gene (DYX3) for dyslexia is located on chromosome 2. Fagerheim, T., Raeymaekers, P., Tønnessen, F.E., Pedersen, M., Tranebjaerg, L., Lubs, H.A. J. Med. Genet. (1999) [Pubmed]
Independent genome-wide scans identify a chromosome 18 quantitative-trait locus influencing dyslexia. Fisher, S.E., Francks, C., Marlow, A.J., MacPhie, I.L., Newbury, D.F., Cardon, L.R., Ishikawa-Brush, Y., Richardson, A.J., Talcott, J.B., Gayán, J., Olson, R.K., Pennington, B.F., Smith, S.D., DeFries, J.C., Stein, J.F., Monaco, A.P. Nat. Genet. (2002) [Pubmed]
DYX1C1 functions in neuronal migration in developing neocortex. Wang, Y., Paramasivam, M., Thomas, A., Bai, J., Kaminen-Ahola, N., Kere, J., Voskuil, J., Rosen, G.D., Galaburda, A.M., Loturco, J.J. Neuroscience (2006) [Pubmed]
Evidence for a susceptibility locus on chromosome 6q influencing phonological coding dyslexia. Petryshen, T.L., Kaplan, B.J., Fu Liu, M., de French, N.S., Tobias, R., Hughes, M.L., Field, L.L. Am. J. Med. Genet. (2001) [Pubmed]
Putative functional alleles of DYX1C1 are not associated with dyslexia susceptibility in a large sample of sibling pairs from the UK. Scerri, T.S., Fisher, S.E., Francks, C., MacPhie, I.L., Paracchini, S., Richardson, A.J., Stein, J.F., Monaco, A.P. J. Med. Genet. (2004) [Pubmed]
Confirmation of a dyslexia susceptibility locus on chromosome 1p34-p36 in a set of 100 Canadian families. Tzenova, J., Kaplan, B.J., Petryshen, T.L., Field, L.L. Am. J. Med. Genet. B Neuropsychiatr. Genet. (2004) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.