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Gene Review

DYX1C1  -  dyslexia susceptibility 1 candidate 1

Homo sapiens

Synonyms: CILD25, DNAAF4, DYX1, DYXC1, Dyslexia susceptibility 1 candidate gene 1 protein, ...
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Psychiatry related information on DYX1C1


High impact information on DYX1C1


Biological context of DYX1C1

  • It will be important to clarify, whether the phenotype caused by DYX1C1 extends to other language-related or comorbid disorders [4].
  • While D1X1C1 is a good candidate gene for DD, we were unable to replicate the original findings between DYX1C1 gene and DD, perhaps due to genetic heterogeneity [5].
  • We directly sequenced exons 2 and 10 of the DYX1C1 gene and found eight single nucleotide polymorphism (SNPs), three of which (-3G>A, 1249 G>T, 1259 C>G) were suitable for the genetic analyses [5].
  • We argue that the different DYX1C1 allele frequencies shown among Italian and Finnish subjects with dyslexia could be attributable to the different linkage disequilibrium structure of these populations [6].
  • We conclude that the polymorphisms identified in the Finland sample are unlikely to be functional DNA changes contributing to dyslexia, and that if variation in EKN1 is causal such changes are more likely to be in regulatory regions that were not sequenced in this study [7].

Other interactions of DYX1C1


  1. A candidate gene for developmental dyslexia encodes a nuclear tetratricopeptide repeat domain protein dynamically regulated in brain. Taipale, M., Kaminen, N., Nopola-Hemmi, J., Haltia, T., Myllyluoma, B., Lyytinen, H., Muller, K., Kaaranen, M., Lindsberg, P.J., Hannula-Jouppi, K., Kere, J. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  2. Linkage analyses of four regions previously implicated in dyslexia: confirmation of a locus on chromosome 15q. Chapman, N.H., Igo, R.P., Thomson, J.B., Matsushita, M., Brkanac, Z., Holzman, T., Berninger, V.W., Wijsman, E.M., Raskind, W.H. Am. J. Med. Genet. B Neuropsychiatr. Genet. (2004) [Pubmed]
  3. DYX1C1 functions in neuronal migration in developing neocortex. Wang, Y., Paramasivam, M., Thomas, A., Bai, J., Kaminen-Ahola, N., Kere, J., Voskuil, J., Rosen, G.D., Galaburda, A.M., Loturco, J.J. Neuroscience (2006) [Pubmed]
  4. Family-based association study of DYX1C1 variants in autism. Ylisaukko-Oja, T., Peyrard-Janvid, M., Lindgren, C.M., Rehnström, K., Vanhala, R., Peltonen, L., Järvelä, I., Kere, J. Eur. J. Hum. Genet. (2005) [Pubmed]
  5. A family-based association study does not support DYX1C1 on 15q21.3 as a candidate gene in developmental dyslexia. Marino, C., Giorda, R., Luisa Lorusso, M., Vanzin, L., Salandi, N., Nobile, M., Citterio, A., Beri, S., Crespi, V., Battaglia, M., Molteni, M. Eur. J. Hum. Genet. (2005) [Pubmed]
  6. No evidence for association between dyslexia and DYX1C1 functional variants in a group of children and adolescents from Southern Italy. Bellini, G., Bravaccio, C., Calamoneri, F., Donatella Cocuzza, M., Fiorillo, P., Gagliano, A., Mazzone, D., del Giudice, E.M., Scuccimarra, G., Militerni, R., Pascotto, A. J. Mol. Neurosci. (2005) [Pubmed]
  7. TDT-association analysis of EKN1 and dyslexia in a Colorado twin cohort. Meng, H., Hager, K., Held, M., Page, G.P., Olson, R.K., Pennington, B.F., Defries, J.C., Smith, S.D., Gruen, J.R. Hum. Genet. (2005) [Pubmed]
  8. Putative functional alleles of DYX1C1 are not associated with dyslexia susceptibility in a large sample of sibling pairs from the UK. Scerri, T.S., Fisher, S.E., Francks, C., MacPhie, I.L., Paracchini, S., Richardson, A.J., Stein, J.F., Monaco, A.P. J. Med. Genet. (2004) [Pubmed]
  9. Developmental disruptions and behavioral impairments in rats following in utero RNAi of Dyx1c1. Threlkeld, S.W., McClure, M.M., Bai, J., Wang, Y., Loturco, J.J., Rosen, G.D., Fitch, R.H. Brain Res. Bull. (2007) [Pubmed]
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