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Gene Review

DCDC2  -  doublecortin domain containing 2

Homo sapiens

Synonyms: DCDC2A, Doublecortin domain-containing protein 2, KIAA1154, Protein RU2S, RU2, ...
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Psychiatry related information on DCDC2


High impact information on DCDC2

  • It is encoded by an antisense transcript, RU2AS, which starts from a cryptic promoter located on the reverse strand of the first intron and ends up on the reverse strand of the RU2S promoter, which contains a polyadenylation signal [2].
  • We searched for linkage disequilibrium (LD) in 137 triads with dyslexia, using markers that span the most-replicated dyslexia susceptibility region on 6p21-p22, and found association between the disease and markers within the VMP/DCDC2/KAAG1 locus [1].
  • Detailed refinement of the LD region, involving sequencing and genotyping of additional markers, showed significant association within DCDC2 in single-marker and haplotype analyses [1].
  • By saturating a previously identified peak of association with single nucleotide polymorphism markers, we identified a large polymorphic deletion that encodes tandem repeats of putative brain-related transcription factor binding sites in intron 2 of DCDC2 [3].
  • RT-PCR data show that DCDC2 localizes to the regions of the brain where fluent reading occurs, and RNA interference studies show that down-regulation alters neuronal migration [3].

Anatomical context of DCDC2


Other interactions of DCDC2


  1. Strong genetic evidence of DCDC2 as a susceptibility gene for dyslexia. Schumacher, J., Anthoni, H., Dahdouh, F., König, I.R., Hillmer, A.M., Kluck, N., Manthey, M., Plume, E., Warnke, A., Remschmidt, H., Hülsmann, J., Cichon, S., Lindgren, C.M., Propping, P., Zucchelli, M., Ziegler, A., Peyrard-Janvid, M., Schulte-Körne, G., Nöthen, M.M., Kere, J. Am. J. Hum. Genet. (2006) [Pubmed]
  2. A new antigen recognized by cytolytic T lymphocytes on a human kidney tumor results from reverse strand transcription. Van Den Eynde, B.J., Gaugler, B., Probst-Kepper, M., Michaux, L., Devuyst, O., Lorge, F., Weynants, P., Boon, T. J. Exp. Med. (1999) [Pubmed]
  3. DCDC2 is associated with reading disability and modulates neuronal development in the brain. Meng, H., Smith, S.D., Hager, K., Held, M., Liu, J., Olson, R.K., Pennington, B.F., DeFries, J.C., Gelernter, J., O'Reilly-Pol, T., Somlo, S., Skudlarski, P., Shaywitz, S.E., Shaywitz, B.A., Marchione, K., Wang, Y., Paramasivam, M., LoTurco, J.J., Page, G.P., Gruen, J.R. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  4. Developmental disruptions and behavioral impairments in rats following in utero RNAi of Dyx1c1. Threlkeld, S.W., McClure, M.M., Bai, J., Wang, Y., Loturco, J.J., Rosen, G.D., Fitch, R.H. Brain Res. Bull. (2007) [Pubmed]
  5. DYX1C1 functions in neuronal migration in developing neocortex. Wang, Y., Paramasivam, M., Thomas, A., Bai, J., Kaminen-Ahola, N., Kere, J., Voskuil, J., Rosen, G.D., Galaburda, A.M., Loturco, J.J. Neuroscience (2006) [Pubmed]
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