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Gene Review

Gvhd1  -  graft-versus-host disease 1

Mus musculus

 
 
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Disease relevance of Gvhd1

 

Psychiatry related information on Gvhd1

  • Whole body images of anesthetized mice taken at various time points after cell infusion revealed the early migration of allogeneic cells to peripheral lymphoid organs, with later infiltration of GVHD target organs [6].
  • RAPA-treated mice had no clinical (e.g., weight loss, diarrhea, lethargy) or histologic evidence of classical acute or chronic GVHD but did develop a clinical-pathological syndrome consisting of ulcerative dermatitis, bile duct proliferation, and a nondestructive peribronchiolar pulmonary infiltration [7].
  • This association was still valid after correcting for other known variables (recipient age, donor-recipient gender relation, type of donor, conditioning regimen, diagnosis, stem cell source and GvHD prophylaxis) by logistic regression (OD=0.391, p=0.023) [8].
 

High impact information on Gvhd1

 

Chemical compound and disease context of Gvhd1

 

Biological context of Gvhd1

 

Anatomical context of Gvhd1

 

Associations of Gvhd1 with chemical compounds

 

Regulatory relationships of Gvhd1

 

Other interactions of Gvhd1

 

Analytical, diagnostic and therapeutic context of Gvhd1

References

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  26. Differential roles of IL-1 and TNF-alpha on graft-versus-host disease and graft versus leukemia. Hill, G.R., Teshima, T., Gerbitz, A., Pan, L., Cooke, K.R., Brinson, Y.S., Crawford, J.M., Ferrara, J.L. J. Clin. Invest. (1999) [Pubmed]
  27. Prevention of lethal murine graft versus host disease by treatment of donor cells with L-leucyl-L-leucine methyl ester. Charley, M., Thiele, D.L., Bennett, M., Lipsky, P.E. J. Clin. Invest. (1986) [Pubmed]
  28. Tumor necrosis factor- alpha production to lipopolysaccharide stimulation by donor cells predicts the severity of experimental acute graft-versus-host disease. Cooke, K.R., Hill, G.R., Crawford, J.M., Bungard, D., Brinson, Y.S., Delmonte, J., Ferrara, J.L. J. Clin. Invest. (1998) [Pubmed]
  29. Interleukin-18 regulates acute graft-versus-host disease by enhancing Fas-mediated donor T cell apoptosis. Reddy, P., Teshima, T., Kukuruga, M., Ordemann, R., Liu, C., Lowler, K., Ferrara, J.L. J. Exp. Med. (2001) [Pubmed]
  30. Interferon-gamma suppresses T-cell proliferation to mitogen via the nitric oxide pathway during experimental acute graft-versus-host disease. Krenger, W., Falzarano, G., Delmonte, J., Snyder, K.M., Byon, J.C., Ferrara, J.L. Blood (1996) [Pubmed]
  31. TNF receptor p55 controls early acute graft-versus-host disease. Speiser, D.E., Bachmann, M.F., Frick, T.W., McKall-Faienza, K., Griffiths, E., Pfeffer, K., Mak, T.W., Ohashi, P.S. J. Immunol. (1997) [Pubmed]
  32. Interleukin-11 promotes T cell polarization and prevents acute graft-versus-host disease after allogeneic bone marrow transplantation. Hill, G.R., Cooke, K.R., Teshima, T., Crawford, J.M., Keith, J.C., Brinson, Y.S., Bungard, D., Ferrara, J.L. J. Clin. Invest. (1998) [Pubmed]
  33. Absence of inducible costimulator on alloreactive T cells reduces graft versus host disease and induces Th2 deviation. Hubbard, V.M., Eng, J.M., Ramirez-Montagut, T., Tjoe, K.H., Muriglan, S.J., Kochman, A.A., Terwey, T.H., Willis, L.M., Schiro, R., Heller, G., Murphy, G.F., Liu, C., Alpdogan, O., van den Brink, M.R. Blood (2005) [Pubmed]
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  35. Both perforin and Fas ligand are required for the regulation of alloreactive CD8+ T cells during acute graft-versus-host disease. Maeda, Y., Levy, R.B., Reddy, P., Liu, C., Clouthier, S.G., Teshima, T., Ferrara, J.L. Blood (2005) [Pubmed]
  36. Total lymphoid irradiation nonmyeloablative preconditioning enriches for IL-4-producing CD4+-TNK cells and skews differentiation of immunocompetent donor CD4+ cells. Rigby, S.M., Rouse, T., Field, E.H. Blood (2003) [Pubmed]
  37. Altered T-cell receptor + CD28-mediated signaling and blocked cell cycle progression in interleukin 10 and transforming growth factor-beta-treated alloreactive T cells that do not induce graft-versus-host disease. Boussiotis, V.A., Chen, Z.M., Zeller, J.C., Murphy, W.J., Berezovskaya, A., Narula, S., Roncarolo, M.G., Blazar, B.R. Blood (2001) [Pubmed]
  38. Adoptive transfer of minor histocompatibility antigen-specific T lymphocytes eradicates leukemia cells without causing graft-versus-host disease. Fontaine, P., Roy-Proulx, G., Knafo, L., Baron, C., Roy, D.C., Perreault, C. Nat. Med. (2001) [Pubmed]
  39. T cells require TRAIL for optimal graft-versus-tumor activity. Schmaltz, C., Alpdogan, O., Kappel, B.J., Muriglan, S.J., Rotolo, J.A., Ongchin, J., Willis, L.M., Greenberg, A.S., Eng, J.M., Crawford, J.M., Murphy, G.F., Yagita, H., Walczak, H., Peschon, J.J., van den Brink, M.R. Nat. Med. (2002) [Pubmed]
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  41. Correction of enzyme deficiency in mice by allogeneic bone marrow transplantation with total lymphoid irradiation. Slavin, S., Yatziv, S. Science (1980) [Pubmed]
 
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