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Gene Review

Plxna3  -  plexin A3

Mus musculus

Synonyms: PlexA3, Plexin-A3, Plxa3, Plxn3, Plxn4, ...
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High impact information on Plxna3

  • Here, we provide evidence that semaphorins, activating the Plexin-A3 receptor, function as retraction inducers to trigger-stereotyped pruning of specific hippocampal mossy fiber and pyramidal axon branches [1].
  • Here, we show that Plexin-A3 and -A4 are key determinants of these responses, through analysis of a Plexin-A3/Plexin-A4 double mutant mouse [2].
  • Here, we show that plexin-A3 is the most ubiquitously expressed plexin family member within regions of the developing mammalian nervous system known to contain semaphorin-responsive neurons [3].
  • Using a chimeric receptor construct, we provide evidence that plexin-A3 can transduce a repulsive signal in growth cones in vitro [3].
  • Expression patterns suggest Plexin-A3/Neuropilin-1 as a candidate receptor in target cells for the regulation of bone innervation by Semaphorin-3A [4].

Biological context of Plxna3


Anatomical context of Plxna3

  • After birth, while the density of innervation decreases, Plexin-A3 is strongly expressed by blood vessels on the ossification front [4].


  1. Stereotyped pruning of long hippocampal axon branches triggered by retraction inducers of the semaphorin family. Bagri, A., Cheng, H.J., Yaron, A., Pleasure, S.J., Tessier-Lavigne, M. Cell (2003) [Pubmed]
  2. Differential requirement for Plexin-A3 and -A4 in mediating responses of sensory and sympathetic neurons to distinct class 3 Semaphorins. Yaron, A., Huang, P.H., Cheng, H.J., Tessier-Lavigne, M. Neuron (2005) [Pubmed]
  3. Plexin-A3 mediates semaphorin signaling and regulates the development of hippocampal axonal projections. Cheng, H.J., Bagri, A., Yaron, A., Stein, E., Pleasure, S.J., Tessier-Lavigne, M. Neuron (2001) [Pubmed]
  4. Expression of Semaphorin-3A and its receptors in endochondral ossification: potential role in skeletal development and innervation. Gomez, C., Burt-Pichat, B., Mallein-Gerin, F., Merle, B., Delmas, P.D., Skerry, T.M., Vico, L., Malaval, L., Chenu, C. Dev. Dyn. (2005) [Pubmed]
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