High impact information on Plxna3

• Here, we provide evidence that semaphorins, activating the Plexin-A3 receptor, function as retraction inducers to trigger-stereotyped pruning of specific hippocampal mossy fiber and pyramidal axon branches [1].
• Here, we show that Plexin-A3 and -A4 are key determinants of these responses, through analysis of a Plexin-A3/Plexin-A4 double mutant mouse [2].
• Here, we show that plexin-A3 is the most ubiquitously expressed plexin family member within regions of the developing mammalian nervous system known to contain semaphorin-responsive neurons [3].
• Using a chimeric receptor construct, we provide evidence that plexin-A3 can transduce a repulsive signal in growth cones in vitro [3].
• Expression patterns suggest Plexin-A3/Neuropilin-1 as a candidate receptor in target cells for the regulation of bone innervation by Semaphorin-3A [4].

Biological context of Plxna3

• Plexin-A3 is not expressed by bone cell lineages in vitro [4].

Anatomical context of Plxna3

• After birth, while the density of innervation decreases, Plexin-A3 is strongly expressed by blood vessels on the ossification front [4].

References