High impact information on Mossy Fibers, Hippocampal

• Here, we provide evidence that semaphorins, activating the Plexin-A3 receptor, function as retraction inducers to trigger-stereotyped pruning of specific hippocampal mossy fiber and pyramidal axon branches [1].
• Presynaptic kainate receptor mediation of frequency facilitation at hippocampal mossy fiber synapses [2].
• Impairment of hippocampal mossy fiber LTD in mice lacking mGluR2 [3].
• Repetitive activation of hippocampal mossy fibers evokes a long-term potentiation (LTP) of synaptic responses in pyramidal cells in the CA3 region that is independent of N-methyl-D-aspartate receptor activation [4].
• Mediation of hippocampal mossy fiber long-term potentiation by cyclic AMP [4].

Biological context of Mossy Fibers, Hippocampal

• Disruption of PLC-beta 1-mediated signal transduction in mutant mice causes age-dependent hippocampal mossy fiber sprouting and neurodegeneration [5].
• Taken together, these data suggest that adenosine endogenous to hippocampal mossy fiber synaptosomes serves to inhibit the release of one of the peptide neuromodulators of this preparation, and provide support for the concept of autoregulation of release [6].
• These results suggest that the predominant excitatory amino acid in hippocampal mossy fiber synaptic transmission may be glutamate and that this synaptic input may be modulated by at least four different products of prodynorphin processing [7].

Anatomical context of Mossy Fibers, Hippocampal

• Two studies by Tashiro et al. and by Hashimoto and Kano in this issue of Neuron provide new insights into the roles of neurotransmitter glutamate release in regulating the motility of hippocampal mossy fiber filopodia and synaptic competition among climbing fibers [8].
• Temporal lobe epilepsy in humans and in rats shows neuronal damage, aberrant sprouting of hippocampal mossy fibers and subsequent synaptic remodeling processes [9].
• In this study, we identified a chloride channel, ClC-3, whose level in synaptic vesicles and hippocampal mossy fiber terminals was reduced in the context of the mocha AP-3 deficiency [10].
• In fact, we have recently shown that such a mechanism occurs in hippocampal mossy fibers, a brain region characterized, like the pancreas, by an important accumulation of zinc and a high density of SUR1-containing KATP [11].
• It was demonstrated that membrane depolarization evoked the release of endogenous glutamate from hippocampal mossy fiber synaptosomes, as well as the accumulation of intraterminal free calcium [12].

Associations of Mossy Fibers, Hippocampal with chemical compounds

• Prenatal exposure to ethanol alters the organization of hippocampal mossy fibers in rats [13].
• Activation of AMPA, kainate, and metabotropic receptors at hippocampal mossy fiber synapses: role of glutamate diffusion [14].
• Dynamic control of presynaptic Ca(2+) inflow by fast-inactivating K(+) channels in hippocampal mossy fiber boutons [15].
• Dynorphin is contained within hippocampal mossy fibers: immunochemical alterations after kainic acid administration and colchicine-induced neurotoxicity [16].
• Adenosine gates synaptic plasticity at hippocampal mossy fiber synapses [17].

Gene context of Mossy Fibers, Hippocampal

• Increased expression of two phospholipase D isoforms during experimentally induced hippocampal mossy fiber outgrowth [18].
• Absence of hippocampal mossy fiber sprouting in transgenic mice overexpressing brain-derived neurotrophic factor [19].
• With the use of an antibody against the calcium-binding protein, calbindin-D28K, in normal autopsy tissue and the neuronal tracers biocytin or biotinylated dextrans in in vitro slice preparations from tissue removed during surgery for intractable epilepsy, we examined the human hippocampal mossy fiber pathway [20].
• Neuropilin-2 regulates the development of selective cranial and sensory nerves and hippocampal mossy fiber projections [21].
• Aberrant expression of neuropeptide Y in hippocampal mossy fibers in the absence of local cell injury following the onset of spike-wave synchronization [22].

References