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Gene Review

acr-6  -  Protein ACR-6

Caenorhabditis elegans

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High impact information on acr-6

  • The candidate gene tar-1 (for Trichostrongylus acetylcholine receptor subunit gene 1) comprising 13704 base pairs was thus identified [1].
  • Hcal is related to unc-38, a nicotinic acetylcholine receptor subunit gene associated with levamisole resistance in Caenorhabditis elegans [2].
  • Together with five other alpha subunit genes described elsewhere by ourselves (unc-38) and other workers (deg-3, acr-4, Ce21 and acr-6), this is now the largest known family of nAChR alpha subunit genes in a single species [3].

Associations of acr-6 with chemical compounds

  • Characterization of an acetylcholine receptor gene of Haemonchus contortus in relation to levamisole resistance [2].

Analytical, diagnostic and therapeutic context of acr-6


  1. Cloning and sequence analysis of the candidate nicotinic acetylcholine receptor alpha subunit gene tar-1 from Trichostrongylus colubriformis. Wiley, L.J., Weiss, A.S., Sangster, N.C., Li, Q. Gene (1996) [Pubmed]
  2. Characterization of an acetylcholine receptor gene of Haemonchus contortus in relation to levamisole resistance. Hoekstra, R., Visser, A., Wiley, L.J., Weiss, A.S., Sangster, N.C., Roos, M.H. Mol. Biochem. Parasitol. (1997) [Pubmed]
  3. An extensive and diverse gene family of nicotinic acetylcholine receptor alpha subunits in Caenorhabditis elegans. Mongan, N.P., Baylis, H.A., Adcock, C., Smith, G.R., Sansom, M.S., Sattelle, D.B. Recept. Channels (1998) [Pubmed]
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