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MeSH Review

Haemonchus

 
 
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Disease relevance of Haemonchus

 

High impact information on Haemonchus

  • Haemonchus contortus GA1 antigens: related, phospholipase C-sensitive, apical gut membrane proteins encoded as a polyprotein and released from the nematode during infection [4].
  • Latrophilin-like receptor from the parasitic nematode Haemonchus contortus as target for the anthelmintic depsipeptide PF1022A [5].
  • Cathepsin B-like cysteine proteases confer intestinal cysteine protease activity in Haemonchus contortus [6].
  • Di- and tetra-oligopeptides were used as fluorogenic substrates and irreversible/competitive inhibitors to establish CBL functions in the intestine of the parasitic nematode Haemonchus contortus [6].
  • A novel mammalian galectin cDNA (ovgal11) was isolated by representational difference analysis from sheep stomach (abomasal) tissue infected with the nematode parasite, Haemonchus contortus [7].
 

Chemical compound and disease context of Haemonchus

 

Biological context of Haemonchus

 

Anatomical context of Haemonchus

  • Pregnant ewes were immunised with a fraction highly enriched in the membrane glycoprotein antigen H11, isolated from the intestinal brush border of adult Haemonchus contortus [14].
  • Substantial protection against the economically important nematode Haemonchus contortus has been achieved by immunizing sheep with a glycoprotein fraction isolated from the intestinal membranes of this parasite [15].
  • We have identified and characterised a homologue of the C. elegans GATA transcription factor elt-2, a central regulator of endoderm development, from the parasitic nematode Haemonchus contortus [16].
  • Helper T cell lines recognizing antigen in the context of MHC Class II molecules were generated from peripheral blood mononuclear cells (PBMC) of sheep undergoing a primary or secondary infection with the nematode parasite Haemonchus contortus [17].
  • Three tubulin isotypes from the parasitic nematode Haemonchus contortus were individually expressed in Escherichia coli, purified, and induced to polymerize into microtubules in the absence of microtubule-associated proteins [18].
 

Associations of Haemonchus with chemical compounds

  • Structural studies on the N-linked oligosaccharides of Haemonchus contortus, an economically important nematode that parasitizes domestic ruminants, have revealed core fucosylation of a type not previously observed in any eukaryotic glycoprotein [19].
  • Genetic variability of the beta-tubulin genes in benzimidazole-susceptible and -resistant strains of Haemonchus contortus [20].
  • Binding of hematin by a new class of glutathione transferase from the blood-feeding parasitic nematode Haemonchus contortus [21].
  • Two alleles of the HG1 gene, which encodes a putative GABA receptor alpha/gamma subunit, were isolated from Haemonchus contortus [22].
  • Specific interaction of benzimidazole anthelmintics with tubulin from developing stages of thiabendazole-susceptible and -resistant Haemonchus contortus [23].
 

Gene context of Haemonchus

  • Detection of P-glycoprotein-mediated multidrug resistance against anthelmintics in Haemonchus contortus using anti-human mdr1 monoclonal antibodies [24].
  • Actin isoforms in the parasitic nematode Haemonchus contortus [25].
  • Haemonchus contortus: cloning and functional expression of a cDNA encoding ornithine decarboxylase and development of a screen for inhibitors [26].
  • Therefore, the molecular mechanism of levamisole resistance in the parasitic nematode Haemonchus contortus was studied by isolating and characterising cDNA clones encoding a putative ligand binding nicotinic acetylcholine receptor subunit, HCAl, of two susceptible and one levamisole resistant population [27].
  • Characterization of an acetylcholine receptor gene of Haemonchus contortus in relation to levamisole resistance [27].
 

Analytical, diagnostic and therapeutic context of Haemonchus

References

  1. Expression of cloned beta-tubulin genes of Haemonchus contortus in Escherichia coli: interaction of recombinant beta-tubulin with native tubulin and mebendazole. Lubega, G.W., Geary, T.G., Klein, R.D., Prichard, R.K. Mol. Biochem. Parasitol. (1993) [Pubmed]
  2. Identification and stage-specific expression of two putative P-glycoprotein coding genes in Onchocerca volvulus. Huang, Y.J., Prichard, R.K. Mol. Biochem. Parasitol. (1999) [Pubmed]
  3. Morphological changes in trichostrongylid eggs after treatment with fenbendazole. Kirsch, R., Schleich, H. Vet. Parasitol. (1982) [Pubmed]
  4. Haemonchus contortus GA1 antigens: related, phospholipase C-sensitive, apical gut membrane proteins encoded as a polyprotein and released from the nematode during infection. Jasmer, D.P., Perryman, L.E., McGuire, T.C. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  5. Latrophilin-like receptor from the parasitic nematode Haemonchus contortus as target for the anthelmintic depsipeptide PF1022A. Saeger, B., Schmitt-Wrede, H.P., Dehnhardt, M., Benten, W.P., Krücken, J., Harder, A., Von Samson-Himmelstjerna, G., Wiegand, H., Wunderlich, F. FASEB J. (2001) [Pubmed]
  6. Cathepsin B-like cysteine proteases confer intestinal cysteine protease activity in Haemonchus contortus. Shompole, S., Jasmer, D.P. J. Biol. Chem. (2001) [Pubmed]
  7. Isolation and characterization of a novel inducible mammalian galectin. Dunphy, J.L., Balic, A., Barcham, G.J., Horvath, A.J., Nash, A.D., Meeusen, E.N. J. Biol. Chem. (2000) [Pubmed]
  8. Efficacy of Fenbendazole against gastrointestinal parasites of sheep. Kennedy, T.J., Todd, A.C. Am. J. Vet. Res. (1975) [Pubmed]
  9. Beta-tubulin genes from the parasitic nematode Haemonchus contortus modulate drug resistance in Caenorhabditis elegans. Kwa, M.S., Veenstra, J.G., Van Dijk, M., Roos, M.H. J. Mol. Biol. (1995) [Pubmed]
  10. Characterization of a novel G-protein coupled receptor from the parasitic nematode H. contortus with high affinity for serotonin. Smith, M.W., Borts, T.L., Emkey, R., Cook, C.A., Wiggins, C.J., Gutierrez, J.A. J. Neurochem. (2003) [Pubmed]
  11. Genomic organization and expression analysis for hcstk, a serine/threonine protein kinase gene of Haemonchus contortus, and comparison with Caenorhabditis elegans par-1. Nikolaou, S., Hartman, D., Nisbet, A.J., Presidente, P.J., Gasser, R.B. Gene (2004) [Pubmed]
  12. Cloning and characterization of a beta-galactoside-binding protein (galectin) from the gut of the gastrointestinal nematode parasite Haemonchus contortus. Newlands, G.F., Skuce, P.J., Knox, D.P., Smith, S.K., Smith, W.D. Parasitology (1999) [Pubmed]
  13. Levamisole binding sites in Haemonchus contortus. Moreno-Guzmán, M.J., Coles, G.C., Jiménez-González, A., Criado-Fornelio, A., Ros-Moreno, R.M., Rodríguez-Caabeiro, F. Int. J. Parasitol. (1998) [Pubmed]
  14. Vaccination of sheep against haemonchosis with H11, a gut membrane-derived protective antigen from the adult parasite: prevention of the periparturient rise and colostral transfer of protective immunity. Andrews, S.J., Hole, N.J., Munn, E.A., Rolph, T.P. Int. J. Parasitol. (1995) [Pubmed]
  15. Metalloendopeptidases from the intestinal brush border of Haemonchus contortus as protective antigens for sheep. Smith, W.D., Newlands, G.F., Smith, S.K., Pettit, D., Skuce, P.J. Parasite Immunol. (2003) [Pubmed]
  16. Ectopic expression of a Haemonchus contortus GATA transcription factor in Caenorhabditis elegans reveals conserved function in spite of extensive sequence divergence. Couthier, A., Smith, J., McGarr, P., Craig, B., Gilleard, J.S. Mol. Biochem. Parasitol. (2004) [Pubmed]
  17. Parasite-specific T cell responses of sheep following live infection with the gastric nematode Haemonchus contortus. Haig, D.M., Windon, R., Blackie, W., Brown, D., Smith, W.D. Parasite Immunol. (1989) [Pubmed]
  18. Individual expression of recombinant alpha- and beta-tubulin from Haemonchus contortus: polymerization and drug effects. Oxberry, M.E., Geary, T.G., Winterrowd, C.A., Prichard, R.K. Protein Expr. Purif. (2001) [Pubmed]
  19. Haemonchus contortus glycoproteins contain N-linked oligosaccharides with novel highly fucosylated core structures. Haslam, S.M., Coles, G.C., Munn, E.A., Smith, T.S., Smith, H.F., Morris, H.R., Dell, A. J. Biol. Chem. (1996) [Pubmed]
  20. Genetic variability of the beta-tubulin genes in benzimidazole-susceptible and -resistant strains of Haemonchus contortus. Beech, R.N., Prichard, R.K., Scott, M.E. Genetics (1994) [Pubmed]
  21. Binding of hematin by a new class of glutathione transferase from the blood-feeding parasitic nematode Haemonchus contortus. van Rossum, A.J., Jefferies, J.R., Rijsewijk, F.A., LaCourse, E.J., Teesdale-Spittle, P., Barrett, J., Tait, A., Brophy, P.M. Infect. Immun. (2004) [Pubmed]
  22. Study of the nematode putative GABA type-A receptor subunits: evidence for modulation by ivermectin. Feng, X.P., Hayashi, J., Beech, R.N., Prichard, R.K. J. Neurochem. (2002) [Pubmed]
  23. Specific interaction of benzimidazole anthelmintics with tubulin from developing stages of thiabendazole-susceptible and -resistant Haemonchus contortus. Lubega, G.W., Prichard, R.K. Biochem. Pharmacol. (1991) [Pubmed]
  24. Detection of P-glycoprotein-mediated multidrug resistance against anthelmintics in Haemonchus contortus using anti-human mdr1 monoclonal antibodies. Kerboeuf, D., Guégnard, F., Vern, Y.L. Parasitol. Res. (2003) [Pubmed]
  25. Actin isoforms in the parasitic nematode Haemonchus contortus. Criado-Fornelio, A., Jimenez-Gonzalez, A., Rodriguez-Caabeiro, F. Parasitol. Res. (1995) [Pubmed]
  26. Haemonchus contortus: cloning and functional expression of a cDNA encoding ornithine decarboxylase and development of a screen for inhibitors. Klein, R.D., Favreau, M.A., Alexander-Bowman, S.J., Nulf, S.C., Vanover, L., Winterrowd, C.A., Yarlett, N., Martinez, M., Keithly, J.S., Zantello, M.R., Thomas, E.M., Geary, T.G. Exp. Parasitol. (1997) [Pubmed]
  27. Characterization of an acetylcholine receptor gene of Haemonchus contortus in relation to levamisole resistance. Hoekstra, R., Visser, A., Wiley, L.J., Weiss, A.S., Sangster, N.C., Roos, M.H. Mol. Biochem. Parasitol. (1997) [Pubmed]
  28. The response of sheep to parenteral vaccination and immunizing infections against the abomasal nematode, Haemonchus contortus. Adams, D.B., Beh, K.J., Davies, H.I. Int. J. Parasitol. (1982) [Pubmed]
  29. Molecular cloning and primary sequence of a cysteine protease expressed by Haemonchus contortus adult worms. Cox, G.N., Pratt, D., Hageman, R., Boisvenue, R.J. Mol. Biochem. Parasitol. (1990) [Pubmed]
  30. Protection induced by vaccinating sheep with a thiol-binding extract of Haemonchus contortus membranes is associated with its protease components. Knox, D.P., Smith, S.K., Redmond, D.L., Smith, W.D. Parasite Immunol. (2005) [Pubmed]
  31. Molecular cloning and characterization of gut-derived cysteine proteinases associated with a host protective extract from Haemonchus contortus. Skuce, P.J., Redmond, D.L., Liddell, S., Stewart, E.M., Newlands, G.F., Smith, W.D., Knox, D.P. Parasitology (1999) [Pubmed]
  32. The effect of immunosuppression with dexamethasone on Haemonchus contortus infections in genetically resistant merino sheep. Presson, B.L., Gray, G.D., Burgess, S.K. Parasite Immunol. (1988) [Pubmed]
 
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