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Gene Review

Nlgn1  -  neuroligin 1

Mus musculus

Synonyms: 6330415N05Rik, BB179718, Kiaa1070, NL1, Neuroligin-1, ...
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Disease relevance of Nlgn1


High impact information on Nlgn1

  • Oligomerization of neuroligin is required for its function, and we find that beta-neurexin clustering is sufficient to trigger the recruitment of synaptic vesicles through interactions that require the cytoplasmic domain of neurexin [2].
  • It is thought to be triggered by members of the neuroligin family of postsynaptic cell adhesion proteins, which may form transsynaptic contacts with presynaptic alpha- and beta-neurexins and have been implicated in the etiology of autism [1].
  • Here we show that the postsynaptic density (PSD) proteins PSD-95 and neuroligin-1 (NLG) are critical for dictating the ratio of excitatory-to-inhibitory synaptic contacts [3].
  • Down-regulation of neuroligin isoform expression by RNA interference results in a loss of excitatory and inhibitory synapses [4].

Other interactions of Nlgn1

  • A balance between excitatory and inhibitory synapses is controlled by PSD-95 and neuroligin [3].


  1. Neuroligins determine synapse maturation and function. Varoqueaux, F., Aramuni, G., Rawson, R.L., Mohrmann, R., Missler, M., Gottmann, K., Zhang, W., Südhof, T.C., Brose, N. Neuron (2006) [Pubmed]
  2. Neurexin mediates the assembly of presynaptic terminals. Dean, C., Scholl, F.G., Choih, J., DeMaria, S., Berger, J., Isacoff, E., Scheiffele, P. Nat. Neurosci. (2003) [Pubmed]
  3. A balance between excitatory and inhibitory synapses is controlled by PSD-95 and neuroligin. Prange, O., Wong, T.P., Gerrow, K., Wang, Y.T., El-Husseini, A. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  4. Control of excitatory and inhibitory synapse formation by neuroligins. Chih, B., Engelman, H., Scheiffele, P. Science (2005) [Pubmed]
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