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Prokr1  -  prokineticin receptor 1

Rattus norvegicus

Synonyms: G-protein coupled receptor 73, G-protein coupled receptor ZAQ, Gpr73, PK-R1, Pkr1, ...
 
 
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High impact information on Prokr1

  • Exogenous IGF-I did not prevent Poly (IC) from activating PKR, but inhibited the Poly (IC)-mediated increase in PKR protein levels [1].
  • We conclude that poly(IC) induces IFN, which mediates the cytostatic effect of poly(IC) on C6 cells at least in part through PKR [2].
  • The PKR inhibitor 2-aminopurine prevented the Poly (IC) stimulation of eIF2-alpha phosphorylation and the Poly (IC)-mediated decrease in IGF-I mRNA [1].
  • Both IGF-I and a blocking antibody against type I interferon (IFN) prevented the increase in PKR levels and the decrease in cell proliferation caused by poly(IC) [2].
  • IGF-I prevents IFN from inducing PKR, thus explaining the ability of IGF-I to reverse the cell cycle blocks and the decreased C6 proliferation caused by poly(IC) [2].
 

Biological context of Prokr1

 

Associations of Prokr1 with chemical compounds

  • Poly (IC) activated double-stranded RNA-activated protein kinase (PKR) at 5 min and increased PKR protein levels at 48 and 72 h [1].
 

Other interactions of Prokr1

References

  1. Double-stranded RNA decreases IGF-I gene expression in a protein kinase R-dependent, but type I interferon-independent, mechanism in C6 rat glioma cells. Chacko, M.S., Adamo, M.L. Endocrinology (2002) [Pubmed]
  2. Double-stranded ribonucleic acid decreases c6 rat glioma cell proliferation in part by activating protein kinase R and decreasing insulin-like growth factor I levels. Chacko, M.S., Ma, X., Adamo, M.L. Endocrinology (2002) [Pubmed]
  3. Biological activities of Bv8 analogues. Negri, L., Lattanzi, R., Giannini, E., Colucci, M.A., Mignogna, G., Barra, D., Grohovaz, F., Codazzi, F., Kaiser, A., Kreil, G., Melchiorri, P. Br. J. Pharmacol. (2005) [Pubmed]
  4. Sensitization of transient receptor potential vanilloid 1 by the prokineticin receptor agonist Bv8. Vellani, V., Colucci, M., Lattanzi, R., Giannini, E., Negri, L., Melchiorri, P., McNaughton, P.A. J. Neurosci. (2006) [Pubmed]
 
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