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Chemical Compound Review

Poly IC     [5-(4-amino-2-oxo-pyrimidin- 1-yl)-3,4...

Synonyms: Poly 1-poly-c, Poly(I:C), NSC-123233, NSC-128576, AC1L6UVD, ...
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Disease relevance of Polyriboinosinic-polyribocytidylic acid


Psychiatry related information on Polyriboinosinic-polyribocytidylic acid


High impact information on Polyriboinosinic-polyribocytidylic acid


Chemical compound and disease context of Polyriboinosinic-polyribocytidylic acid


Biological context of Polyriboinosinic-polyribocytidylic acid


Anatomical context of Polyriboinosinic-polyribocytidylic acid

  • To examine whether dsRNA and CpG DNA could combine to provide enhanced stimulation of innate immune cells, murine macrophages were stimulated with poly-rI:rC (pIC), a dsRNA analog, and CpG-containing oligodeoxynucleotides (CpG-ODN) [22].
  • The inhibitory activity was seen even with 0.2 ml of the 10,000-fold dilution of the fluid and with its filtrate passed through a Diaflo UM-10 membrane (greater than 10,000-dalton exclusion), However, such tumor ascitic fluids did not affect the induction of type I interferon in mice by polyriboinosinic-polyribocytidylic acid or tilorone-HCl [23].
  • Coisogenic diabetes-resistant (DR) BB/Wor rats do not develop diabetes spontaneously, but IDDM can readily be induced by treatment with polyinosinic:polycytidylic acid and depletion of RT6+ T-cells [24].
  • The effects of polyinosinic:polycytidylic acid (pI:C) on the graft-vs-host (GVH) reaction. II. Increased NK-mediated rejection on C57BL/6 lymphocytes by (C57BL/6 X A)F1 mice [25].
  • Human monocytes were cultured for 24 h in serum-free AIM-V medium, followed by 24-h maturation by polyriboinosinic polyribocytidylic acid (polyI:C) [26].

Associations of Polyriboinosinic-polyribocytidylic acid with other chemical compounds


Gene context of Polyriboinosinic-polyribocytidylic acid


Analytical, diagnostic and therapeutic context of Polyriboinosinic-polyribocytidylic acid


  1. Nitric oxide inhibits hepatitis B virus replication in the livers of transgenic mice. Guidotti, L.G., McClary, H., Loudis, J.M., Chisari, F.V. J. Exp. Med. (2000) [Pubmed]
  2. Hybrid resistance to EL-4 lymphoma cells. I. Characterization of natural killer cells that lyse EL-4 cells and their distinction from marrow-dependent natural killer cells. Kumar, V., Luevano, E., Bennett, M. J. Exp. Med. (1979) [Pubmed]
  3. A phase I-II trial of multiple-dose polyriboinosic-polyribocytidylic acid in patieonts with leukemia or solid tumors. Robinson, R.A., DeVita, V.T., Levy, H.B., Baron, S., Hubbard, S.P., Levine, A.S. J. Natl. Cancer Inst. (1976) [Pubmed]
  4. Alterations of interferon production in a mouse model of thermal injury. Suzuki, F., Pollard, R.B. J. Immunol. (1982) [Pubmed]
  5. Poly I:C activated macrophages are tumoricidal for TNF-alpha-resistant 3LL tumor cells. Remels, L., Fransen, L., Huygen, K., De Baetselier, P. J. Immunol. (1990) [Pubmed]
  6. Increase in transforming growth factor-beta in the brain during infection is related to fever, not depression of spontaneous motor activity. Matsumura, S., Shibakusa, T., Fujikawa, T., Yamada, H., Inoue, K., Fushiki, T. Neuroscience (2007) [Pubmed]
  7. Effect of poly rI:rC treatment upon the metabolism of [14C]-paracetamol in the BALB/cJ mouse. Dolphin, C.T., Caldwell, J., Smith, R.L. Biochem. Pharmacol. (1987) [Pubmed]
  8. Polyriboinosinic:polyribocytidylic acid enhances rabbit slow-wave sleep. Krueger, J.M., Majde, J.A., Blatteis, C.M., Endsley, J., Ahokas, R.A., Cady, A.B. Am. J. Physiol. (1988) [Pubmed]
  9. Monoclonal antibodies which distinguish between human NK cells and cytotoxic T lymphocytes. Zarling, J.M., Kung, P.C. Nature (1980) [Pubmed]
  10. Enhancement of IgE-mediated histamine release from human basophils by viruses: role of interferon. Ida, S., Hooks, J.J., Siraganian, R.P., Notkins, A.L. J. Exp. Med. (1977) [Pubmed]
  11. Enhancement of human interferon production by neutral red and chloroquine: analysis of inhibition of protein degradation and macromolecular synthesis. Sehgal, P.B., Tamm, I., Vilcek, J. J. Exp. Med. (1975) [Pubmed]
  12. Kinetics of depression and recovery of murine hepatic cytochrome P-450 levels after treatment with the interferon inducer polyriboinosinic-polyribocytidylic acid. Crowe, D.O., Reiners, J.J., Nerland, D.E., Sonnenfeld, G. J. Natl. Cancer Inst. (1986) [Pubmed]
  13. TLR agonists regulate PDGF-B production and cell proliferation through TGF-beta/type I IFN crosstalk. Chow, E.K., O'connell, R.M., Schilling, S., Wang, X.F., Fu, X.Y., Cheng, G. EMBO J. (2005) [Pubmed]
  14. Depression of humoral immunity to sheep erythrocytes in vitro by Friend virus leukemic spleen cells: induction of resistance by statolon. Weislow, O.S., Wheelock, E.F. J. Immunol. (1975) [Pubmed]
  15. Enhanced therapeutic efficacy of poly(ICLC) and ribavirin combinations against Rift Valley fever virus infection in mice. Kende, M., Lupton, H.W., Rill, W.L., Levy, H.B., Canonico, P.G. Antimicrob. Agents Chemother. (1987) [Pubmed]
  16. Ethanol decreases natural killer cell activation but only minimally affects anatomical distribution after administration of polyinosinic:polycytidylic acid: role in resistance to B16F10 melanoma. Hébert, P., Pruett, S.B. Alcohol. Clin. Exp. Res. (2003) [Pubmed]
  17. Role of antigen-presenting cells in variation in immunogenicity of mycobacteria. Shroff, K.E., Sainis, K.B., Sengupta, S.R., Kamat, R.S. Clin. Exp. Immunol. (1990) [Pubmed]
  18. Suppression of NK-mediated natural resistance by interferon treatment of murine lymphomas. Greenberg, A.H., Miller, V., Jablonski, T., Pohajdak, B. J. Immunol. (1984) [Pubmed]
  19. The iddm4 locus segregates with diabetes susceptibility in congenic WF.iddm4 rats. Mordes, J.P., Leif, J., Novak, S., DeScipio, C., Greiner, D.L., Blankenhorn, E.P. Diabetes (2002) [Pubmed]
  20. Susceptibility to diabetes is widely distributed in normal class IIu haplotype rats. Ellerman, K.E., Like, A.A. Diabetologia (2000) [Pubmed]
  21. Production of interferon-beta upon induction with polyinosinic acid:polycytidylic acid during the cell cycle of human fibroblasts. Tang, K.F., Ts'o, P.O., Lesko, S.A. Exp. Cell Res. (1989) [Pubmed]
  22. Synergistic activation of innate immunity by double-stranded RNA and CpG DNA promotes enhanced antitumor activity. Whitmore, M.M., DeVeer, M.J., Edling, A., Oates, R.K., Simons, B., Lindner, D., Williams, B.R. Cancer Res. (2004) [Pubmed]
  23. Impaired induction of type II interferon in tumor-bearing mice. Matsubara, S., Suzuki, M., Ishida, N. Cancer Res. (1980) [Pubmed]
  24. Dietary cow's milk protein does not alter the frequency of diabetes in the BB rat. Malkani, S., Nompleggi, D., Hansen, J.W., Greiner, D.L., Mordes, J.P., Rossini, A.A. Diabetes (1997) [Pubmed]
  25. The effects of polyinosinic:polycytidylic acid (pI:C) on the graft-vs-host (GVH) reaction. II. Increased NK-mediated rejection on C57BL/6 lymphocytes by (C57BL/6 X A)F1 mice. Peres, A., Nestel, F.P., Seemayer, T.A., Lapp, W.S. J. Immunol. (1986) [Pubmed]
  26. Messenger RNA electroporation of human monocytes, followed by rapid in vitro differentiation, leads to highly stimulatory antigen-loaded mature dendritic cells. Ponsaerts, P., Van den Bosch, G., Cools, N., Van Driessche, A., Nijs, G., Lenjou, M., Lardon, F., Van Broeckhoven, C., Van Bockstaele, D.R., Berneman, Z.N., Van Tendeloo, V.F. J. Immunol. (2002) [Pubmed]
  27. Conditioned augmentation of natural killer cell activity. Independence from nociceptive effects and dependence on interferon-beta. Solvason, H.B., Ghanta, V.K., Hiramoto, R.N. J. Immunol. (1988) [Pubmed]
  28. Modified polyriboinosinic-polyribocytidylic acid, an immunological adjuvant. Houston, W.E., Crabbs, C.L., Stephen, E.L., Levy, H.B. Infect. Immun. (1976) [Pubmed]
  29. Prophylactic control of simian hemorrhagic fever in monkeys by an interferon inducer, polyriboinosinic-polyribocytidylic acid-poly-L-lysine. Levy, H.B., London, W., Fuccillo, D.A., Baron, S., Rice, J. J. Infect. Dis. (1976) [Pubmed]
  30. Double-stranded RNA decreases IGF-I gene expression in a protein kinase R-dependent, but type I interferon-independent, mechanism in C6 rat glioma cells. Chacko, M.S., Adamo, M.L. Endocrinology (2002) [Pubmed]
  31. Cytokine induction in mice by the immunomodulator imiquimod. Reiter, M.J., Testerman, T.L., Miller, R.L., Weeks, C.E., Tomai, M.A. J. Leukoc. Biol. (1994) [Pubmed]
  32. p38 MAPK activation controls the TLR3-mediated up-regulation of cytotoxicity and cytokine production in human NK cells. Pisegna, S., Pirozzi, G., Piccoli, M., Frati, L., Santoni, A., Palmieri, G. Blood (2004) [Pubmed]
  33. Viral infection causes rapid sensitization to lipopolysaccharide: central role of IFN-alpha beta. Nansen, A., Randrup Thomsen, A. J. Immunol. (2001) [Pubmed]
  34. TLR3 Ligation Activates an Antiviral Response in Human Fetal Astrocytes: A Role for Viperin/cig5. Rivieccio, M.A., Suh, H.S., Zhao, Y., Zhao, M.L., Chin, K.C., Lee, S.C., Brosnan, C.F. J. Immunol. (2006) [Pubmed]
  35. Interleukin 1 and poly(rI).poly(rC) induce production of a hybridoma growth factor by human fibroblasts. Van Damme, J., Cayphas, S., Opdenakker, G., Billiau, A., Van Snick, J. Eur. J. Immunol. (1987) [Pubmed]
  36. TLR agonists abrogate costimulation blockade-induced prolongation of skin allografts. Thornley, T.B., Brehm, M.A., Markees, T.G., Shultz, L.D., Mordes, J.P., Welsh, R.M., Rossini, A.A., Greiner, D.L. J. Immunol. (2006) [Pubmed]
  37. Double-stranded RNA inhibits beta-cell function and induces islet damage by stimulating beta-cell production of nitric oxide. Heitmeier, M.R., Scarim, A.L., Corbett, J.A. J. Biol. Chem. (1999) [Pubmed]
  38. Anti-CD2 monoclonal antibodies prevent spontaneous and adoptive transfer of diabetes in the BB/Wor rat. Barlow, A.K., Like, A.A. Am. J. Pathol. (1992) [Pubmed]
  39. Differences in mouse interferons according to cell source and mode of induction. Maehara, N., Ho, M., Armstrong, J.A. Infect. Immun. (1977) [Pubmed]
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