Gene Review:
Eif2s1 - eukaryotic translation initiation factor 2...
Rattus norvegicus
Synonyms:
Eif2a, Eukaryotic translation initiation factor 2 subunit 1, Eukaryotic translation initiation factor 2 subunit alpha, eIF-2-alpha, eIF-2A, ...
- Cloning and sequencing of complementary DNAs encoding the alpha-subunit of translational initiation factor eIF-2. Characterization of the protein and its messenger RNA. Ernst, H., Duncan, R.F., Hershey, J.W. J. Biol. Chem. (1987)
- Cloning and characterization of cDNA encoding rat hemin-sensitive initiation factor-2 alpha (eIF-2 alpha) kinase. Evidence for multitissue expression. Mellor, H., Flowers, K.M., Kimball, S.R., Jefferson, L.S. J. Biol. Chem. (1994)
- The intraischemic and early reperfusion changes of protein synthesis in the rat brain. eIF-2 alpha kinase activity and role of initiation factors eIF-2 alpha and eIF-4E. Burda, J., Martín, M.E., Gottlieb, M., Chavko, M., Marsala, J., Alcázar, A., Pavón, M., Fando, J.L., Salinas, M. J. Cereb. Blood Flow Metab. (1998)
- Upregulation of iNOS expression and phosphorylation of eIF-2alpha are paralleled by suppression of protein synthesis in rat hypothalamus in a closed head trauma model. Petrov, T., Underwood, B.D., Braun, B., Alousi, S.S., Rafols, J.A. J. Neurotrauma (2001)
- Regulation of eukaryotic initiation factor-2 expression during sepsis. Vary, T.C., Jurasinski, C.V., Karinch, A.M., Kimball, S.R. Am. J. Physiol. (1994)
- The eukaryotic initiation factor 2-associated 67-kDa polypeptide (p67) plays a critical role in regulation of protein synthesis initiation in animal cells. Ray, M.K., Datta, B., Chakraborty, A., Chattopadhyay, A., Meza-Keuthen, S., Gupta, N.K. Proc. Natl. Acad. Sci. U.S.A. (1992)
- Transforming growth factor-alpha attenuates N-methyl-D-aspartic acid toxicity in cortical cultures by preventing protein synthesis inhibition through an Erk1/2-dependent mechanism. Petegnief, V., Friguls, B., Sanfeliu, C., Suñol, C., Planas, A.M. J. Biol. Chem. (2003)
- Mechanism of inhibition of peptide chain initiation by amino acid deprivation in perfused rat liver. Regulation involving inhibition of eukaryotic initiation factor 2 alpha phosphatase activity. Kimball, S.R., Antonetti, D.A., Brawley, R.M., Jefferson, L.S. J. Biol. Chem. (1991)
- Alpha subunit of eukaryotic translational initiation factor-2 is a heat-shock protein. Colbert, R.A., Hucul, J.A., Scorsone, K.A., Young, D.A. J. Biol. Chem. (1987)
- Oxidative damage to the endoplasmic reticulum is implicated in ischemic neuronal cell death. Hayashi, T., Saito, A., Okuno, S., Ferrand-Drake, M., Dodd, R.L., Nishi, T., Maier, C.M., Kinouchi, H., Chan, P.H. J. Cereb. Blood Flow Metab. (2003)
- Reversible inhibition of the protein phosphatase 1 by hydrogen peroxide. Potential regulation of eIF2 alpha phosphorylation in differentiated PC12 cells. O'Loghlen, A., Pérez-Morgado, M.I., Salinas, M., Martín, M.E. Arch. Biochem. Biophys. (2003)
- Upregulated expression of the genes encoding translation initiation factors eIF-4E and eIF-2alpha in transformed cells. Rosenwald, I.B. Cancer Lett. (1996)
- Phosphorylation of the alpha subunit of initiation factor 2 correlates with the inhibition of translation following transient cerebral ischaemia in the rat. Burda, J., Martín, M.E., García, A., Alcázar, A., Fando, J.L., Salinas, M. Biochem. J. (1994)
- Modulation of translation initiation in rat skeletal muscle and liver in response to food intake. Yoshizawa, F., Kimball, S.R., Jefferson, L.S. Biochem. Biophys. Res. Commun. (1997)
- Glucose stimulates the activity of the guanine nucleotide-exchange factor eIF-2B in isolated rat islets of Langerhans. Gilligan, M., Welsh, G.I., Flynn, A., Bujalska, I., Diggle, T.A., Denton, R.M., Proud, C.G., Docherty, K. J. Biol. Chem. (1996)
- Mechanism of the inhibition of protein synthesis by vasopressin in rat liver. Kimball, S.R., Jefferson, L.S. J. Biol. Chem. (1990)
- Carbonyl cyanide p-trifluoromethoxyphenylhydrazone (FCCP) induces initiation factor 2 alpha phosphorylation and translation inhibition in PC12 cells. Muñoz, F., Martín, M.E., Salinas, M., Fando, J.L. FEBS Lett. (2001)
- Brefeldin A inhibits protein synthesis through the phosphorylation of the alpha-subunit of eukaryotic initiation factor-2. Mellor, H., Kimball, S.R., Jefferson, L.S. FEBS Lett. (1994)
- Reactive cysteines of the 90-kDa heat shock protein, Hsp90. Nardai, G., Sass, B., Eber, J., Orosz, G., Csermely, P. Arch. Biochem. Biophys. (2000)
- Resistance of initiation factor 2 (eIF-2alpha) kinases to staurosporine: an approach for assaying the kinases in crude extracts. Martín de la Vega, C., García, A., Martín, M.E., Alcázar, A., Marin, O., Quevedo, C., Salinas, M. Cell. Signal. (1999)
- Elevated gadd153/chop expression and enhanced c-Jun N-terminal protein kinase activation sensitizes aged cells to ER stress. Li, J., Holbrook, N.J. Exp. Gerontol. (2004)
- Effect of brain ischemia and reperfusion on the localization of phosphorylated eukaryotic initiation factor 2 alpha. DeGracia, D.J., Sullivan, J.M., Neumar, R.W., Alousi, S.S., Hikade, K.R., Pittman, J.E., White, B.C., Rafols, J.A., Krause, G.S. J. Cereb. Blood Flow Metab. (1997)
- Translational initiation factor eIF-2 subcellular levels and phosphorylation status in the developing rat brain. Martín, M.E., Alcázar, A., Fando, J.L., García, A.M., Salinas, M. Neurosci. Lett. (1993)
- Rat fibroblasts transfected with the human 70-kDa heat shock gene exhibit altered translation and eukaryotic initiation factor 2 alpha phosphorylation following heat shock. Chang, G.C., Liu, R., Panniers, R., Li, G.C. International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group. (1994)
- Molecular cloning and sequencing of the human heme-regulated eukaryotic initiation factor 2 alpha (eIF-2 alpha) kinase from bone marrow culture. Omasa, T., Chen, Y.G., Mantalaris, A., Tsai, Y.C., Wu, J.H. DNA Seq. (2002)