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Gene Review

SDR16C5  -  short chain dehydrogenase/reductase family...

Homo sapiens

Synonyms: EPHD-2, Epidermal retinol dehydrogenase 2, RDH#2, RDH-E2, RDHE2, ...
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Disease relevance of RDHE2

  • Qualitative RT-PCR demonstrated that the mRNA levels of hRDH-E2 were significantly elevated in the affected skin in psoriasis patients as compared to the unaffected skin in patients and the normal skin in healthy individual [1].

High impact information on RDHE2

  • hRDH-E2 gene polymorphisms, variable transcriptional start sites, and psoriasis [2].
  • The gene encoding hRDH-E2 is located on Chromosome 8 close to a candidate region for psoriasis and therefore is a functional and positional candidate for this disorder [2].
  • In the present study, the transcription start sites for hRDH-E2 gene transcription in the lung were found to be more upstream of those that were identified previously in keratinocytes [2].
  • hRDH-E2 is a member of the short-chain alcohol dehydrogenase/reductase (SDR) family that converts retinol to retinaldehyde as the first and rate-limiting step in the retinoic acid synthetic pathway [2].
  • Consequently, differences in the nucleotide sequence were determined for all of the coding exons, untranslated regions, and at least 2850 bp of 5'-noncoding sequence of hRDH-E2 by direct sequencing of polymerase chain reaction (PCR)-amplified DNA samples obtained from 8 psoriatic patients and 8 healthy controls [2].

Chemical compound and disease context of RDHE2


Biological context of RDHE2


Other interactions of RDHE2


  1. Identification of the hRDH-E2 gene, a novel member of the SDR family, and its increased expression in psoriatic lesion. Matsuzaka, Y., Okamoto, K., Tsuji, H., Mabuchi, T., Ozawa, A., Tamiya, G., Inoko, H. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  2. hRDH-E2 gene polymorphisms, variable transcriptional start sites, and psoriasis. Matsuzaka, Y., Okamoto, K., Yoshikawa, Y., Takaki, A., Oka, A., Mabuchi, T., Iizuka, M., Ozawa, A., Tamiya, G., Kulski, J.K., Inoko, H. Mamm. Genome (2004) [Pubmed]
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