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Gene Review

GKN2  -  gastrokine 2

Homo sapiens

Synonyms: BLOT, BRICD1B, Blottin, Down-regulated in gastric cancer, GDDR, ...
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Disease relevance of GKN2


High impact information on GKN2


Other interactions of GKN2

  • The TFF1 protein partner is a previously unknown protein that we have called TFIZ1 for trefoil factor interactions(z) 1 [3].

Analytical, diagnostic and therapeutic context of GKN2


  1. Identification of blottin: a novel gastric trefoil factor family-2 binding protein. Otto, W.R., Patel, K., McKinnell, I., Evans, M.D., Lee, C.Y., Frith, D., Hanrahan, S., Blight, K., Blin, N., Kayademir, T., Poulsom, R., Jeffery, R., Hunt, T., Wright, N.A., McGregor, F., Oien, K.A. Proteomics (2006) [Pubmed]
  2. Decreased expression of gastrokine 1 and the trefoil factor interacting protein TFIZ1/GKN2 in gastric cancer: influence of tumor histology and relationship to prognosis. Moss, S.F., Lee, J.W., Sabo, E., Rubin, A.K., Rommel, J., Westley, B.R., May, F.E., Gao, J., Meitner, P.A., Tavares, R., Resnick, M.B. Clin. Cancer Res. (2008) [Pubmed]
  3. Interaction between TFF1, a gastric tumor suppressor trefoil protein, and TFIZ1, a brichos domain-containing protein with homology to SP-C. Westley, B.R., Griffin, S.M., May, F.E. Biochemistry (2005) [Pubmed]
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