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Gene Review:

GKN2 - gastrokine 2

Homo sapiens

Synonyms: BLOT, BRICD1B, Blottin, Down-regulated in gastric cancer, GDDR, ...

Otto, W.R. et al., Westley, B.R. et al., Moss, S.F. et al.

Steven F. Moss, Jin-Woo Lee, Edmond Sabo, Anna K. Rubin, John Rommel, Bruce R. Westley, Felicity E. B. May, John Gao, Patricia A. Meitner, Rose Tavares, Murray B. Resnick,

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Disease relevance of GKN2

Previous work showed that blottin is down-regulated in gastric cancers [1] .
Loss of GKN1 and GKN2 expression occurs frequently in gastric adenocarcinomas, especially in the diffuse subtype [2].

High impact information on GKN2

Interaction between TFF1, a gastric tumor suppressor trefoil protein, and TFIZ1, a brichos domain-containing protein with homology to SP-C [3].
TFIZ1 mRNA was cloned from gastric mucosa and sequenced [3].
Cultured HT-29 cells express blottin and show increased DNA synthesis with antiblottin antibody; however, this effect is reversed by the immunising peptide [1].
ISH of gastrointestinal tissues shows abundant blottin mRNA in gastric surface and foveolar epithelium [1].
Identification of blottin: a novel gastric trefoil factor family-2 binding protein [1].

Other interactions of GKN2

The TFF1 protein partner is a previously unknown protein that we have called TFIZ1 for trefoil factor interactions(z) 1 [3].

Analytical, diagnostic and therapeutic context of GKN2

IHC shows cytoplasmic staining for blottin protein, and by immunoelectron microscopy in mucus granules and Golgi stacks [1].

References

Identification of blottin: a novel gastric trefoil factor family-2 binding protein. Otto, W.R., Patel, K., McKinnell, I., Evans, M.D., Lee, C.Y., Frith, D., Hanrahan, S., Blight, K., Blin, N., Kayademir, T., Poulsom, R., Jeffery, R., Hunt, T., Wright, N.A., McGregor, F., Oien, K.A. Proteomics (2006) [Pubmed]
Decreased expression of gastrokine 1 and the trefoil factor interacting protein TFIZ1/GKN2 in gastric cancer: influence of tumor histology and relationship to prognosis. Moss, S.F., Lee, J.W., Sabo, E., Rubin, A.K., Rommel, J., Westley, B.R., May, F.E., Gao, J., Meitner, P.A., Tavares, R., Resnick, M.B. Clin. Cancer Res. (2008) [Pubmed]
Interaction between TFF1, a gastric tumor suppressor trefoil protein, and TFIZ1, a brichos domain-containing protein with homology to SP-C. Westley, B.R., Griffin, S.M., May, F.E. Biochemistry (2005) [Pubmed]

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