Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

Rtkn - rhotekin

Mus musculus

Synonyms: Rhotekin

Ito, H. et al., Reynaud, C. et al.

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High impact information on Rtkn

Mutation of the serine and valine residues to alanine impairs interaction of rhotekin with TIP-1 [1].
Rhotekin was found to associate with PIST in vitro and in both polarized and non-polarized MDCK (Madin-Darby canine kidney) cells [2].
Among various effector proteins for the small GTPase Rho, the function(s) of Rhotekin is (are) almost unknown [2].
Immunofluorescence analyses revealed the co-localization of PIST and Rhotekin at the Golgi apparatus in non-polarized fibroblast-like MDCK cells and AJs (adherens junctions) in the fully polarized cells [2].
PIST and Rhotekin are recruited from the cytosol to AJs as the cell becomes polarized [2].

References

The PDZ protein TIP-1 interacts with the Rho effector rhotekin and is involved in Rho signaling to the serum response element. Reynaud, C., Fabre, S., Jalinot, P. J. Biol. Chem. (2000) [Pubmed]
Identification of a PDZ protein, PIST, as a binding partner for Rho effector Rhotekin: biochemical and cell-biological characterization of Rhotekin-PIST interaction. Ito, H., Iwamoto, I., Morishita, R., Nozawa, Y., Asano, T., Nagata, K. Biochem. J. (2006) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

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