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Gene Review:

Gopc - golgi associated PDZ and coiled-coil motif...

Mus musculus

Synonyms: 2210402P09Rik, AI844555, CAL, FIG, GOPC1, ...

Ito, H. et al., Catena, R. et al., Suzuki-Toyota, F. et al.

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High impact information on Gopc

In acrosome-deficient round spermatids of hrb -/- and gopc -/- mice, H1T2 localization is not altered, indicating that proper acrosome development is not required for specifying nuclear polarity [1].
The GOPC-deficient spermatozoa provide a valuable model not only for head but also for tail anomalies [2].
Rhotekin was found to associate with PIST in vitro and in both polarized and non-polarized MDCK (Madin-Darby canine kidney) cells [3].
Immunofluorescence analyses revealed the co-localization of PIST and Rhotekin at the Golgi apparatus in non-polarized fibroblast-like MDCK cells and AJs (adherens junctions) in the fully polarized cells [3].
PIST and Rhotekin are recruited from the cytosol to AJs as the cell becomes polarized [3].

Physical interactions of Gopc

The C-terminal SPV (Ser-Pro-Val) motif of Rhotekin exhibited binding to the PDZ domain of PIST [3].

References

Changes in intranuclear chromatin architecture induce bipolar nuclear localization of histone variant H1T2 in male haploid spermatids. Catena, R., Ronfani, L., Sassone-Corsi, P., Davidson, I. Dev. Biol. (2006) [Pubmed]
The coiled tail of the round-headed spermatozoa appears during epididymal passage in GOPC-deficient mice. Suzuki-Toyota, F., Ito, C., Toyama, Y., Maekawa, M., Yao, R., Noda, T., Toshimori, K. Arch. Histol. Cytol. (2004) [Pubmed]
Identification of a PDZ protein, PIST, as a binding partner for Rho effector Rhotekin: biochemical and cell-biological characterization of Rhotekin-PIST interaction. Ito, H., Iwamoto, I., Morishita, R., Nozawa, Y., Asano, T., Nagata, K. Biochem. J. (2006) [Pubmed]

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