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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

AIM1  -  absent in melanoma 1

Homo sapiens

Synonyms: Absent in melanoma 1 protein, Beta/gamma crystallin domain-containing protein 1, CRYBG1, ST4
 
 
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Disease relevance of AIM1

  • AIM1 is a novel gene whose expression is associated with the experimental reversal of tumorigenicity of human malignant melanoma [1].
 

High impact information on AIM1

  • AIM1 is a good candidate for the putative suppressor of malignant melanoma on chromosome 6, possibly exerting its effects through interactions with the cytoskeleton [1].
  • The structure of the AIM1 gene shows remarkable similarity to beta-crystallin genes, with homologous introns delineating equivalent protein structural units [1].
  • Deletions of PTEN/MMAC1 on 10q23.3 and AIM1 on 6q21 as well as mutations of ras gene are involved in the later progression stages of melanoma [2].
 

Analytical, diagnostic and therapeutic context of AIM1

References

  1. AIM1, a novel non-lens member of the betagamma-crystallin superfamily, is associated with the control of tumorigenicity in human malignant melanoma. Ray, M.E., Wistow, G., Su, Y.A., Meltzer, P.S., Trent, J.M. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  2. Recent advances in melanoma research. Saida, T. J. Dermatol. Sci. (2001) [Pubmed]
  3. Crystallization and preliminary X-ray crystallographic investigations on a betagamma-crystallin domain of absent in melanoma 1 (AIM1), a protein from Homo sapiens. Aravind, P., Rajini, B., Sharma, Y., Sankaranarayanan, R. Acta Crystallograph. Sect. F Struct. Biol. Cryst. Commun. (2006) [Pubmed]
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