The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

AIM1  -  absent in melanoma 1

Homo sapiens

Synonyms: Absent in melanoma 1 protein, Beta/gamma crystallin domain-containing protein 1, CRYBG1, ST4
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of AIM1

  • AIM1 is a novel gene whose expression is associated with the experimental reversal of tumorigenicity of human malignant melanoma [1].

High impact information on AIM1

  • AIM1 is a good candidate for the putative suppressor of malignant melanoma on chromosome 6, possibly exerting its effects through interactions with the cytoskeleton [1].
  • The structure of the AIM1 gene shows remarkable similarity to beta-crystallin genes, with homologous introns delineating equivalent protein structural units [1].
  • Deletions of PTEN/MMAC1 on 10q23.3 and AIM1 on 6q21 as well as mutations of ras gene are involved in the later progression stages of melanoma [2].

Analytical, diagnostic and therapeutic context of AIM1


  1. AIM1, a novel non-lens member of the betagamma-crystallin superfamily, is associated with the control of tumorigenicity in human malignant melanoma. Ray, M.E., Wistow, G., Su, Y.A., Meltzer, P.S., Trent, J.M. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  2. Recent advances in melanoma research. Saida, T. J. Dermatol. Sci. (2001) [Pubmed]
  3. Crystallization and preliminary X-ray crystallographic investigations on a betagamma-crystallin domain of absent in melanoma 1 (AIM1), a protein from Homo sapiens. Aravind, P., Rajini, B., Sharma, Y., Sankaranarayanan, R. Acta Crystallograph. Sect. F Struct. Biol. Cryst. Commun. (2006) [Pubmed]
WikiGenes - Universities