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Gene Review

Sema3c  -  sema domain, immunoglobulin domain (Ig),...

Mus musculus

Synonyms: 1110036B02Rik, SemE, Sema E, Semae, Semaphorin-3C, ...
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Disease relevance of Sema3c


High impact information on Sema3c

  • Similarly to SemD, the secreted semaphorins SemA and SemE display repulsive properties that are regulated by processing [2].
  • The aberrant development of axonal connections in absence of Pax6 function appear to be related to ultrastructural defects of cells along the PSPB, as well as to a failure of axonal guidance molecule expression, including Sema3c and Sema5a [3].
  • Specific binding sites for Semaphorin D and Semaphorin E were present on cortical fibers both in vitro and in vivo at the time when corticofugal projections are established [4].
  • Attractive effects were only observed when growth cones encountered increasing concentrations or a patterned distribution of Semaphorin E, but not when they are exposed to uniform concentrations of this molecule [4].
  • Strikingly, EphA5 and Sema3c, which encode repulsive guidance cues, were down-regulated in the Ngn2 and Ngn1;Ngn2 mutant germinal zones, providing a possible molecular basis for axonal targeting defects [5].

Biological context of Sema3c


  1. Identification of semaphorin E gene expression in metastatic human lung adenocarcinoma cells by mRNA differential display. Martín-Satué, M., Blanco, J. Journal of surgical oncology. (1999) [Pubmed]
  2. The chemorepulsive activity of secreted semaphorins is regulated by furin-dependent proteolytic processing. Adams, R.H., Lohrum, M., Klostermann, A., Betz, H., Püschel, A.W. EMBO J. (1997) [Pubmed]
  3. Pax6 is required for the normal development of the forebrain axonal connections. Jones, L., López-Bendito, G., Gruss, P., Stoykova, A., Molnár, Z. Development (2002) [Pubmed]
  4. Semaphorins act as attractive and repulsive guidance signals during the development of cortical projections. Bagnard, D., Lohrum, M., Uziel, D., Püschel, A.W., Bolz, J. Development (1998) [Pubmed]
  5. A screen for downstream effectors of Neurogenin2 in the embryonic neocortex. Mattar, P., Britz, O., Johannes, C., Nieto, M., Ma, L., Rebeyka, A., Klenin, N., Polleux, F., Guillemot, F., Schuurmans, C. Dev. Biol. (2004) [Pubmed]
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