Disease relevance of Sema3c

• CONCLUSION: Our results point to the relevance of semaphorin E in metastatic spread of human lung adenocarcinoma cells [1].

High impact information on Sema3c

• Similarly to SemD, the secreted semaphorins SemA and SemE display repulsive properties that are regulated by processing [2].
• The aberrant development of axonal connections in absence of Pax6 function appear to be related to ultrastructural defects of cells along the PSPB, as well as to a failure of axonal guidance molecule expression, including Sema3c and Sema5a [3].
• Specific binding sites for Semaphorin D and Semaphorin E were present on cortical fibers both in vitro and in vivo at the time when corticofugal projections are established [4].
• Attractive effects were only observed when growth cones encountered increasing concentrations or a patterned distribution of Semaphorin E, but not when they are exposed to uniform concentrations of this molecule [4].
• Strikingly, EphA5 and Sema3c, which encode repulsive guidance cues, were down-regulated in the Ngn2 and Ngn1;Ngn2 mutant germinal zones, providing a possible molecular basis for axonal targeting defects [5].

Biological context of Sema3c

• Identification of semaphorin E gene expression in metastatic human lung adenocarcinoma cells by mRNA differential display [1].

References