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Gene Review

Sema3a  -  sema domain, immunoglobulin domain (Ig),...

Mus musculus

Synonyms: Hsema-I, SEMA1, SemD, Sema D, Sema III, ...
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Disease relevance of Sema3a


High impact information on Sema3a


Biological context of Sema3a


Anatomical context of Sema3a


Associations of Sema3a with chemical compounds

  • The N-terminal encodes a semaphorin domain that is similar between Sema I-III [6] followed by a single putative immunoglobulin-like domain, a transmembrane domain, and a proline-rich intracellular domain [11].
  • Antibodies directed against a conserved collapsin-derived peptide provided marked and prolonged protection of several neuronal cell types from dopamine-induced apoptosis [12].

Physical interactions of Sema3a


Other interactions of Sema3a


Analytical, diagnostic and therapeutic context of Sema3a

  • To identify structures that express semaIII/coll-1 in developing mammals, we cloned the rat homologue and performed in situ hybridization on embryonic, neonatal, and adult rats [15].


  1. Disruption of semaphorin III/D gene causes severe abnormality in peripheral nerve projection. Taniguchi, M., Yuasa, S., Fujisawa, H., Naruse, I., Saga, S., Mishina, M., Yagi, T. Neuron (1997) [Pubmed]
  2. A novel action of collapsin: collapsin-1 increases antero- and retrograde axoplasmic transport independently of growth cone collapse. Goshima, Y., Kawakami, T., Hori, H., Sugiyama, Y., Takasawa, S., Hashimoto, Y., Kagoshima-Maezono, M., Takenaka, T., Misu, Y., Strittmatter, S.M. J. Neurobiol. (1997) [Pubmed]
  3. Semaphorin III is needed for normal patterning and growth of nerves, bones and heart. Behar, O., Golden, J.A., Mashimo, H., Schoen, F.J., Fishman, M.C. Nature (1996) [Pubmed]
  4. The semaphorin 4D receptor controls invasive growth by coupling with Met. Giordano, S., Corso, S., Conrotto, P., Artigiani, S., Gilestro, G., Barberis, D., Tamagnone, L., Comoglio, P.M. Nat. Cell Biol. (2002) [Pubmed]
  5. Neuropilin-1 extracellular domains mediate semaphorin D/III-induced growth cone collapse. Nakamura, F., Tanaka, M., Takahashi, T., Kalb, R.G., Strittmatter, S.M. Neuron (1998) [Pubmed]
  6. The chemorepulsive activity of secreted semaphorins is regulated by furin-dependent proteolytic processing. Adams, R.H., Lohrum, M., Klostermann, A., Betz, H., Püschel, A.W. EMBO J. (1997) [Pubmed]
  7. Growth cone neuropilin-1 mediates collapsin-1/Sema III facilitation of antero- and retrograde axoplasmic transport. Goshima, Y., Hori, H., Sasaki, Y., Yang, T., Kagoshima-Maezono, M., Li, C., Takenaka, T., Nakamura, F., Takahashi, T., Strittmatter, S.M., Misu, Y., Kawakami, T. J. Neurobiol. (1999) [Pubmed]
  8. Semaphorin 3C regulates endothelial cell function by increasing integrin activity. Banu, N., Teichman, J., Dunlap-Brown, M., Villegas, G., Tufro, A. FASEB J. (2006) [Pubmed]
  9. Ventral migration of early-born neurons requires Dcc and is essential for the projections of primary afferents in the spinal cord. Ding, Y.Q., Kim, J.Y., Xu, Y.S., Rao, Y., Chen, Z.F. Development (2005) [Pubmed]
  10. Semaphorins III and IV repel hippocampal axons via two distinct receptors. Chédotal, A., Del Rio, J.A., Ruiz, M., He, Z., Borrell, V., de Castro, F., Ezan, F., Goodman, C.S., Tessier-Lavigne, M., Sotelo, C., Soriano, E. Development (1998) [Pubmed]
  11. Identification of a member of mouse semaphorin family. Inagaki, S., Furuyama, T., Iwahashi, Y. FEBS Lett. (1995) [Pubmed]
  12. Semaphorins as mediators of neuronal apoptosis. Shirvan, A., Ziv, I., Fleminger, G., Shina, R., He, Z., Brudo, I., Melamed, E., Barzilai, A. J. Neurochem. (1999) [Pubmed]
  13. Mouse semaphorin H inhibits neurite outgrowth from sensory neurons. Miyazaki, N., Furuyama, T., Amasaki, M., Sugimoto, H., Sakai, T., Takeda, N., Kubo, T., Inagaki, S. Neurosci. Res. (1999) [Pubmed]
  14. Semaphorin 3A growth cone collapse requires a sequence homologous to tarantula hanatoxin. Behar, O., Mizuno, K., Badminton, M., Woolf, C.J. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  15. Anatomy of rat semaphorin III/collapsin-1 mRNA expression and relationship to developing nerve tracts during neuroembryogenesis. Giger, R.J., Wolfer, D.P., De Wit, G.M., Verhaagen, J. J. Comp. Neurol. (1996) [Pubmed]
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