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Gene Review

Sema3b  -  sema domain, immunoglobulin domain (Ig),...

Mus musculus

Synonyms: AW208495, LUCA-1, SemA, Sema, Sema A, ...
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High impact information on Sema3b

  • This mannolipid was believed to be synthesized from endogenous retinyl phosphate and was tentatively identified as retinyl phosphate mannose (Ret-P-Man) (De Luca, L. M., Brugh, M. R. Silverman-Jones, C. S. and Shidoji, Y. (1982) Biochem. J. 208, 159-170) [1].
  • Other semaphorins, including Sema3C, 4A, 4F and the cancer invasion associated Sema 4D were also expressed in the mouse mammary gland along with the semaphorin receptors, Plexins A2, A3, B2, and D1, and Neuropilins 1 and 2 [2].
  • Our previous work has shown that dietary retinoic acid (RA) is necessary for skin tumor formation induced by the two-stage protocol with the initiator 7,12-dimethylbenz[a]anthracene (DMBA) and the promoter 12-O-tetradecanoyl phorbol-13-acetate (TPA) (De Luca et al., Cancer Res., 36 (1976) 2334-2339) [3].
  • Sema 3C-induced MGEC adhesion was prevented by integrin blocking antibodies and involved beta1 integrin serine phosphorylation [4].
  • Sema 3A expressed by endothelial cells controls vascular morphogenesis through integrin inhibition [4].


  1. Mannosylation of endogenous and exogenous phosphatidic acid by liver microsomal membranes. Formation of phosphatidylmannose. Creek, K.E., Rimoldi, D., Clifford, A.J., Silverman-Jones, C.S., De Luca, L.M. J. Biol. Chem. (1986) [Pubmed]
  2. Involvement of axonal guidance proteins and their signaling partners in the developing mouse mammary gland. Morris, J.S., Stein, T., Pringle, M.A., Davies, C.R., Weber-Hall, S., Ferrier, R.K., Bell, A.K., Heath, V.J., Gusterson, B.A. J. Cell. Physiol. (2006) [Pubmed]
  3. Dietary retinoids are essential for skin papilloma formation induced by either the two-stage or the complete tumorigenesis model in female SENCAR mice. De Luca, L.M., Sly, L., Jones, C.S., Chen, L.C. Cancer Lett. (1992) [Pubmed]
  4. Semaphorin 3C regulates endothelial cell function by increasing integrin activity. Banu, N., Teichman, J., Dunlap-Brown, M., Villegas, G., Tufro, A. FASEB J. (2006) [Pubmed]
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