High impact information on Smr2

• The mouse Vcs2 gene is a composite structure which evolved by gene fusion and encodes five distinct salivary mRNA species [1].
• Vcs2 is thus a single gene that arose by the fusion of three genes (or pseudogenes) of the VCS multigene family [1].
• These cDNAs encode three novel proteins, designated MSG1, MSG2 and MSG3 [2].
• The Vcs2 gene is the first example of a mouse androgen-regulated gene that is expressed in SMG acinar cells [3].
• In contrast, Vcs2 transcripts were found only in the acinar cells of the submandibular glands (SMGs) of male mice, in which they are expressed in response to androgens [3].

Other interactions of Smr2

• No Vcs2 transcripts were detected in the SMGs of females or castrated males by Northern blot, RNase protection, or in situ hybridization [3].

Analytical, diagnostic and therapeutic context of Smr2

• In situ hybridization was used to study the cell-specific expression of two new mouse VCS genes, Vcs1 and Vcs2 [3].

References